ID:RGS12_MOUSE DESCRIPTION: RecName: Full=Regulator of G-protein signaling 12; Short=RGS12; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. SUBUNIT: Interacts with GNAI1, GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in brain. DEVELOPMENTAL STAGE: Expressed in germinal vesicle oocyte, metaphase II oocyte and blastocyst (at protein level). Expressed in oocyte. DOMAIN: The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3 (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 GoLoco domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 PID domain. SIMILARITY: Contains 2 RBD (Ras-binding) domains. SIMILARITY: Contains 1 RGS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00595 - PDZ domain (Also known as DHR or GLGF) PF00615 - Regulator of G protein signaling domain PF02188 - GoLoco motif PF02196 - Raf-like Ras-binding domain PF16611 - Unstructured region between RBD and GoLoco PF16612 - C-terminal unstructured region of RGS12 PF16613 - Unstructured region of RGS12
ModBase Predicted Comparative 3D Structure on Q8CGE9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
