ID:S4A4_MOUSE DESCRIPTION: RecName: Full=Electrogenic sodium bicarbonate cotransporter 1; Short=Sodium bicarbonate cotransporter; AltName: Full=Na(+)/HCO3(-) cotransporter; AltName: Full=Solute carrier family 4 member 4; FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. ENZYME REGULATION: Inhibited by stilbene derivatives and regulated by cyclic AMP. SUBUNIT: Interacts with CA2/carbonic anhydrase 2 and CA4/carbonic anhydrase 4 which may regulate transporter activity. SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Isoform 1 is specifically expressed in pancreatic ducts and acini. Also expressed in parotid acinar cells and in the colonic crypts. PTM: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1 (By similarity). PTM: N-glycosylated. May not be necessary for the transporter basic functions. SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00955 - HCO3- transporter family PF07565 - Band 3 cytoplasmic domain
SCOP Domains: 55804 - Phoshotransferase/anion transport protein
ModBase Predicted Comparative 3D Structure on O88343
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.