ID:CNO6L_MOUSE DESCRIPTION: RecName: Full=CCR4-NOT transcription complex subunit 6-like; EC=3.1.-.-; FUNCTION: Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA (By similarity). COFACTOR: Magnesium (By similarity). SUBUNIT: Component of the CCR4-NOT complex at least composed of CNOT1, CNOT2, CNOT3, CNOT8, CNOT9, CNOT10 and TNKS1BP1 (By similarity). Interacts with NANOS2. SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: Belongs to the CCR4/nocturin family. SIMILARITY: Contains 4 LRR (leucine-rich) repeats. SEQUENCE CAUTION: Sequence=BAC26790.1; Type=Frameshift; Positions=38, 64;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8VEG6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
