ID:TRUA_MOUSE DESCRIPTION: RecName: Full=tRNA pseudouridine synthase A, mitochondrial; EC=5.4.99.12; AltName: Full=tRNA pseudouridine(38-40) synthase; AltName: Full=tRNA pseudouridylate synthase I; AltName: Full=tRNA-uridine isomerase I; Flags: Precursor; FUNCTION: Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA. Isoforms 3 and 4 do not form pseudouridine when expressed in vitro. CATALYTIC ACTIVITY: tRNA uridine(38-40) = tRNA pseudouridine(38- 40). SUBUNIT: Forms a complex with RARG and the SRA1 RNA in the nucleus. SUBCELLULAR LOCATION: Isoform 1: Mitochondrion (By similarity). SUBCELLULAR LOCATION: Isoform 2: Nucleus (By similarity). SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family. SEQUENCE CAUTION: Sequence=BAA95047.1; Type=Frameshift; Positions=230; Sequence=BAC40817.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9WU56
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
