ID:UNG_MOUSE DESCRIPTION: RecName: Full=Uracil-DNA glycosylase; Short=UDG; EC=3.2.2.27; FUNCTION: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. CATALYTIC ACTIVITY: Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. SUBUNIT: Monomer (By similarity). Interacts with FAM72A (By similarity). SUBCELLULAR LOCATION: Isoform 1: Mitochondrion. SUBCELLULAR LOCATION: Isoform 2: Nucleus. PTM: Isoform 1 is processed by cleavage of a transit peptide. SIMILARITY: Belongs to the uracil-DNA glycosylase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P97931
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003684 damaged DNA binding GO:0004844 uracil DNA N-glycosylase activity GO:0016787 hydrolase activity GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0043024 ribosomal small subunit binding
Biological Process: GO:0006281 DNA repair GO:0006284 base-excision repair GO:0006974 cellular response to DNA damage stimulus GO:0016446 somatic hypermutation of immunoglobulin genes GO:0016447 somatic recombination of immunoglobulin gene segments GO:0043066 negative regulation of apoptotic process GO:0045830 positive regulation of isotype switching GO:0097510 base-excision repair, AP site formation via deaminated base removal
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03410 - Base excision repair mmu05340 - Primary immunodeficiency
Reactome (by CSHL, EBI, and GO)
Protein P97931 (Reactome details) participates in the following event(s):
R-MMU-110349 Displacement of UNG glycosylase by APEX1 at the AP site R-MMU-110215 Cleavage of uracil by UNG glycosylase R-MMU-110217 Cleavage of 5-hydroxyluracil by UNG glycosylase R-MMU-110357 Displacement of DNA glycosylase by APEX1 R-MMU-110329 Cleavage of the damaged pyrimidine R-MMU-73933 Resolution of Abasic Sites (AP sites) R-MMU-73928 Depyrimidination R-MMU-73884 Base Excision Repair R-MMU-73929 Base-Excision Repair, AP Site Formation R-MMU-73894 DNA Repair