Mouse Gene Caln1 (ENSMUST00000111287.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. (from UniProt Q9JJG7) Gencode Transcript: ENSMUST00000111287.7 Gencode Gene: ENSMUSG00000060371.12 Transcript (Including UTRs) Position: mm10 chr5:130,448,012-130,840,636 Size: 392,625 Total Exon Count: 6 Strand: + Coding Region Position: mm10 chr5:130,506,071-130,839,410 Size: 333,340 Coding Exon Count: 5
ID:CABP8_MOUSE DESCRIPTION: RecName: Full=Calcium-binding protein 8; Short=CaBP8; AltName: Full=Calneuron I; AltName: Full=Calneuron-1; FUNCTION: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner (By similarity). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Cell membrane; Single-pass type IV membrane protein (By similarity). TISSUE SPECIFICITY: Brain-specific. High expression in the cerebellum, hippocampus, and cortex. DEVELOPMENTAL STAGE: Shows little prenatal expression, with highest expression at postnatal day 21. DOMAIN: The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting (By similarity). SIMILARITY: Contains 2 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9JJG7
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
