Mouse Gene Cox19 (ENSMUST00000049630.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus cytochrome c oxidase assembly protein 19 (Cox19), mRNA. (from RefSeq NM_197980)
Gencode Transcript: ENSMUST00000049630.12
Gencode Gene: ENSMUSG00000045438.12
Transcript (Including UTRs)
   Position: mm10 chr5:139,336,189-139,345,233 Size: 9,045 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chr5:139,338,291-139,345,153 Size: 6,863 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:139,336,189-139,345,233)mRNA (may differ from genome)Protein (92 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: COX19_MOUSE
DESCRIPTION: RecName: Full=Cytochrome c oxidase assembly protein COX19;
FUNCTION: May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity).
SIMILARITY: Belongs to the COX19 family.
SIMILARITY: Contains 1 CHCH domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.0080-0.250 Picture PostScript Text
3' UTR -728.302102-0.346 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010625 - CHCH
IPR009069 - MTCP1

SCOP Domains:
47072 - Cysteine alpha-hairpin motif

ModBase Predicted Comparative 3D Structure on Q8K0C8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBankRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0006878 cellular copper ion homeostasis
GO:0009060 aerobic respiration
GO:0033617 mitochondrial respiratory chain complex IV assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK148526 - Mus musculus adult pancreas islet cells cDNA, RIKEN full-length enriched library, clone:C820017L04 product:hypothetical protein, full insert sequence.
AK013289 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810442C17 product:unclassifiable, full insert sequence.
BC031792 - Mus musculus COX19 cytochrome c oxidase assembly homolog (S. cerevisiae), mRNA (cDNA clone MGC:18796 IMAGE:4193998), complete cds.
AK007984 - Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810074D02 product:RIKEN cDNA 1810074D02 gene, full insert sequence.
AK003697 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110014H13 product:unclassifiable, full insert sequence.
AK002486 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610010J06 product:RIKEN cDNA 2810437L13 gene, full insert sequence.
AK013260 - Mus musculus 10, 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2810437L13 product:RIKEN cDNA 2810437L13 gene, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: COX19_MOUSE, NM_197980, Q8K0C8, uc009agj.1, uc009agj.2
UCSC ID: uc009agj.2
RefSeq Accession: NM_197980
Protein: Q8K0C8 (aka COX19_MOUSE)
CCDS: CCDS39350.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.