ID:EIF3B_MOUSE DESCRIPTION: RecName: Full=Eukaryotic translation initiation factor 3 subunit B; Short=eIF3b; AltName: Full=Eukaryotic translation initiation factor 3 subunit 9; AltName: Full=eIF-3-eta; AltName: Full=eIF3 p116; FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Interacts with UPF2 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex may also interact with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation may lead to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The RRM domain mediates interaction with EIF3J (By similarity). PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation (By similarity). DISRUPTION PHENOTYPE: Embryonic death. SIMILARITY: Belongs to the eIF-3 subunit B family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SIMILARITY: Contains 5 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8JZQ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK170938 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630211E12 product:eukaryotic translation initiation factor 3, subunit 9 (eta), full insert sequence. AK033722 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130232K10 product:EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 9 (EIF-3 ETA) (EIF3 P116) (EIF3 P110) homolog [Homo sapiens], full insert sequence. AK167618 - Mus musculus 12 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530025F11 product:eukaryotic translation initiation factor 3, subunit 9 (eta), full insert sequence. AK089978 - Mus musculus RCB-0559 K-1 . F1 cDNA, RIKEN full-length enriched library, clone:G430041C21 product:EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 9 (EIF-3 ETA) (EIF3 P116) (EIF3 P110) homolog [Homo sapiens], full insert sequence. BC031704 - Mus musculus eukaryotic translation initiation factor 3, subunit B, mRNA (cDNA clone MGC:25599 IMAGE:4023277), complete cds. BC023767 - Mus musculus eukaryotic translation initiation factor 3, subunit B, mRNA (cDNA clone MGC:38325 IMAGE:5343631), complete cds. BC051065 - Mus musculus eukaryotic translation initiation factor 3, subunit B, mRNA (cDNA clone MGC:59168 IMAGE:5343631), complete cds. AK195154 - Mus musculus cDNA, clone:Y1G0117I22, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK214205 - Mus musculus cDNA, clone:Y2G0131A15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. BC007175 - Mus musculus eukaryotic translation initiation factor 3, subunit B, mRNA (cDNA clone IMAGE:3493441), partial cds. AK204322 - Mus musculus cDNA, clone:Y1G0147P19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK198242 - Mus musculus cDNA, clone:Y1G0127I21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK206288 - Mus musculus cDNA, clone:Y2G0104F18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK194329 - Mus musculus cDNA, clone:Y1G0115A02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK203889 - Mus musculus cDNA, clone:Y1G0146I21, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK202933 - Mus musculus cDNA, clone:Y1G0143D08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK204353 - Mus musculus cDNA, clone:Y1G0148C01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK190217 - Mus musculus cDNA, clone:Y1G0102B13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK190362 - Mus musculus cDNA, clone:Y1G0102I08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK193854 - Mus musculus cDNA, clone:Y1G0113J01, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK193918 - Mus musculus cDNA, clone:Y1G0113M02, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK196728 - Mus musculus cDNA, clone:Y1G0122L19, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK198886 - Mus musculus cDNA, clone:Y1G0129H13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK199123 - Mus musculus cDNA, clone:Y1G0130D21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK204714 - Mus musculus cDNA, clone:Y1G0149G09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK211352 - Mus musculus cDNA, clone:Y2G0121H15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK219469 - Mus musculus cDNA, clone:Y2G0148J02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK189975 - Mus musculus cDNA, clone:Y1G0101F21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK202262 - Mus musculus cDNA, clone:Y1G0140O06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK218594 - Mus musculus cDNA, clone:Y2G0145K22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK219456 - Mus musculus cDNA, clone:Y2G0148I09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK218044 - Mus musculus cDNA, clone:Y2G0143N05, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK205605 - Mus musculus cDNA, clone:Y2G0102D21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000069974, based on BLAT search. AK202344 - Mus musculus cDNA, clone:Y1G0141D03, strand:unspecified. AK014117 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110032P20 product:weakly similar to EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 9 (EIF-3 ETA) (EIF3 P116) (EIF3 P110) [Homo sapiens], full insert sequence. AK186302 - Mus musculus cDNA, clone:Y0G0136O07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000031544, based on BLAT search. AK211163 - Mus musculus cDNA, clone:Y2G0120N15, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000031544, based on BLAT search. AK203959 - Mus musculus cDNA, clone:Y1G0146N07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000031544, based on BLAT search.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu03013 - RNA transport
Reactome (by CSHL, EBI, and GO)
Protein Q8JZQ9 (Reactome details) participates in the following event(s):
R-MMU-72676 eIF3 and eIF1A bind to the 40S subunit R-MMU-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-MMU-72691 Formation of the 43S pre-initiation complex R-MMU-72621 Ribosomal scanning R-MMU-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-MMU-72689 Formation of a pool of free 40S subunits R-MMU-72649 Translation initiation complex formation R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex R-MMU-72737 Cap-dependent Translation Initiation R-MMU-72702 Ribosomal scanning and start codon recognition R-MMU-156827 L13a-mediated translation R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-MMU-72613 Eukaryotic Translation Initiation R-MMU-72766 Translation R-MMU-392499 Metabolism of proteins