ID:BI2L1_MOUSE DESCRIPTION: RecName: Full=Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Short=BAI1-associated protein 2-like protein 1; AltName: Full=Insulin receptor tyrosine kinase substrate; FUNCTION: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity). SUBUNIT: Interacts with RAC1. Binds to F-actin. Interacts with FASLG (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity). TISSUE SPECIFICITY: Detected in bladder, liver, testes, heart, lung, spleen, brain and skeletal muscle (at protein level). DOMAIN: The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation (By similarity). PTM: Phosphorylated on tyrosine in response to insulin (By similarity). SIMILARITY: Contains 1 IMD (IRSp53/MIM homology) domain. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9DBJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
