Mouse Gene Ttc26 (ENSMUST00000162554.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus tetratricopeptide repeat domain 26 (Ttc26), mRNA. (from RefSeq NM_153600)
Gencode Transcript: ENSMUST00000162554.7
Gencode Gene: ENSMUSG00000056832.14
Transcript (Including UTRs)
   Position: mm10 chr6:38,381,469-38,427,647 Size: 46,179 Total Exon Count: 18 Strand: +
Coding Region
   Position: mm10 chr6:38,381,591-38,425,239 Size: 43,649 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:38,381,469-38,427,647)mRNA (may differ from genome)Protein (554 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: TTC26_MOUSE
DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 26; Short=TPR repeat protein 26;
FUNCTION: May play a critical role in ciliogenesis and normal cilia function.
SUBCELLULAR LOCATION: Cell projection, cilium. Note=Localizes at the base to the ciliary transition zone.
TISSUE SPECIFICITY: High expression detected in testis. Detected also retina, kidney, lung and brain tissue. The expression level is low in liver and spleen.
SIMILARITY: Contains 4 TPR repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -46.70122-0.383 Picture PostScript Text
3' UTR -695.102408-0.289 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical

Pfam Domains:
PF12895 - Anaphase-promoting complex, cyclosome, subunit 3
PF13181 - Tetratricopeptide repeat

SCOP Domains:
48371 - ARM repeat
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
140726 - AF0941-like

ModBase Predicted Comparative 3D Structure on Q8BS45
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007224 smoothened signaling pathway
GO:0007286 spermatid development
GO:0008594 photoreceptor cell morphogenesis
GO:0015031 protein transport
GO:0042073 intraciliary transport
GO:0046530 photoreceptor cell differentiation
GO:0060271 cilium assembly

Cellular Component:
GO:0005813 centrosome
GO:0005929 cilium
GO:0030992 intraciliary transport particle B
GO:0036064 ciliary basal body
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  AK035185 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430097H08 product:hypothetical protein, full insert sequence.
BC066060 - Mus musculus tetratricopeptide repeat domain 26, mRNA (cDNA clone MGC:90074 IMAGE:6848602), complete cds.
BC031513 - Mus musculus tetratricopeptide repeat domain 26, mRNA (cDNA clone IMAGE:3603623), complete cds.
BC066087 - Mus musculus tetratricopeptide repeat domain 26, mRNA (cDNA clone IMAGE:30534196).
AK087919 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330040K20 product:unclassifiable, full insert sequence.
AK034018 - Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330141E21 product:unclassifiable, full insert sequence.
AK086670 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930044O21 product:CDNA FLJ12571 FIS, CLONE NT2RM4000950 homolog [Homo sapiens], full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8BS45 (Reactome details) participates in the following event(s):

R-MMU-5624949 Assembly of the anterograde IFT train
R-MMU-5620924 Intraflagellar transport
R-MMU-5617833 Cilium Assembly
R-MMU-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: NM_153600, Q8BS45, TTC26_MOUSE, uc009bkc.1, uc009bkc.2
UCSC ID: uc009bkc.2
RefSeq Accession: NM_153600
Protein: Q8BS45 (aka TTC26_MOUSE)
CCDS: CCDS51750.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.