Mouse Gene Hoxa11 (ENSMUST00000048026.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus homeobox A11 (Hoxa11), mRNA. (from RefSeq NM_010450) RefSeq Summary (NM_010450): This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is important in the development of the skeleton, limbs, and urogenital tract. Expression of this gene may be regulated by overlapping transcription from an adjacent locus on the opposite strand (GeneID: 15397). [provided by RefSeq, Mar 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENSMUST00000048026.9 Gencode Gene: ENSMUSG00000038210.10 Transcript (Including UTRs) Position: mm10 chr6:52,242,106-52,245,810 Size: 3,705 Total Exon Count: 2 Strand: - Coding Region Position: mm10 chr6:52,243,360-52,245,719 Size: 2,360 Coding Exon Count: 2
ID:HXA11_MOUSE DESCRIPTION: RecName: Full=Homeobox protein Hox-A11; AltName: Full=Homeobox protein Hox-1.9; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. INTERACTION: O88513:Gmnn; NbExp=2; IntAct=EBI-445941, EBI-445922; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the Abd-B homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31311
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.