Mouse Gene Pex26 (ENSMUST00000088561.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus peroxisomal biogenesis factor 26 (Pex26), transcript variant 1, mRNA. (from RefSeq NM_028730) RefSeq Summary (NM_028730): This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]. Gencode Transcript: ENSMUST00000088561.9 Gencode Gene: ENSMUSG00000067825.11 Transcript (Including UTRs) Position: mm10 chr6:121,183,667-121,196,192 Size: 12,526 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chr6:121,184,265-121,193,615 Size: 9,351 Coding Exon Count: 5
ID:PEX26_MOUSE DESCRIPTION: RecName: Full=Peroxisome assembly protein 26; AltName: Full=Peroxin-26; FUNCTION: Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (By similarity). SUBUNIT: Interacts directly with PEX6 via its cytoplasmic domain. Interacts indirectly with PEX1, via its interaction with PEX6 (By similarity). SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass type II membrane protein (By similarity). SIMILARITY: Belongs to the peroxin-26 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8BGI5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04146 - Peroxisome
Reactome (by CSHL, EBI, and GO)
Protein Q8BGI5 (Reactome details) participates in the following event(s):
R-MMU-9033516 Ub:PEX5L (in PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14) binds PEX1:PEX6:PEX26 and ZFAND6 R-MMU-9033533 Ub:PEX5S,L (in PEX2:PEX10:PEX12:Ub:PEX5S:PEX13:PEX14) binds PEX1:PEX6:PEX26 and ZFAND6 R-MMU-9033241 Peroxisomal protein import R-MMU-392499 Metabolism of proteins
US Server
