Mouse Gene Gng8 (ENSMUST00000078182.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus guanine nucleotide binding protein (G protein), gamma 8 (Gng8), mRNA. (from RefSeq NM_010320)
Gencode Transcript: ENSMUST00000078182.5
Gencode Gene: ENSMUSG00000063594.5
Transcript (Including UTRs)
   Position: mm10 chr7:16,891,786-16,895,425 Size: 3,640 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr7:16,894,944-16,895,363 Size: 420 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:16,891,786-16,895,425)mRNA (may differ from genome)Protein (70 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q3UMY0_MOUSE
DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein subunit gamma;
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity).
SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the G protein gamma family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -224.50635-0.354 Picture PostScript Text
3' UTR -2.6062-0.042 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015898 - G-protein_gamma-like_dom
IPR001770 - Gprotein-gamma

Pfam Domains:
PF00631 - GGL domain

SCOP Domains:
48670 - Transducin (heterotrimeric G protein), gamma chain

ModBase Predicted Comparative 3D Structure on Q3UMY0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003924 GTPase activity
GO:0004871 signal transducer activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0035176 social behavior
GO:0043584 nose development
GO:0071444 cellular response to pheromone

Cellular Component:
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  LF202690 - JP 2014500723-A/10193: Polycomb-Associated Non-Coding RNAs.
AK144609 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730009J10 product:guanine nucleotide binding protein (G protein), gamma 8 subunit, full insert sequence.
BC111437 - Mus musculus guanine nucleotide binding protein (G protein), gamma 8, mRNA (cDNA clone MGC:130528 IMAGE:40049157), complete cds.
MA438267 - JP 2018138019-A/10193: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04062 - Chemokine signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_16549, NM_010320, Q3UMY0, Q3UMY0_MOUSE, uc009fik.1, uc009fik.2
UCSC ID: uc009fik.2
RefSeq Accession: NM_010320
Protein: Q3UMY0 CCDS: CCDS20856.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.