Mouse Gene Fosb (ENSMUST00000003640.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus FBJ osteosarcoma oncogene B (Fosb), transcript variant 1, mRNA. (from RefSeq NM_008036)
Gencode Transcript: ENSMUST00000003640.3
Gencode Gene: ENSMUSG00000003545.3
Transcript (Including UTRs)
   Position: mm10 chr7:19,302,696-19,310,051 Size: 7,356 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr7:19,304,841-19,309,431 Size: 4,591 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:19,302,696-19,310,051)mRNA (may differ from genome)Protein (338 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: FOSB_MOUSE
DESCRIPTION: RecName: Full=Protein fosB;
FUNCTION: FosB interacts with Jun proteins enhancing their DNA binding activity.
SUBUNIT: Heterodimer (By similarity).
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: By growth factors.
SIMILARITY: Belongs to the bZIP family. Fos subfamily.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -242.10620-0.390 Picture PostScript Text
3' UTR -769.102145-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR000837 - Leuzip_Fos

Pfam Domains:
PF00170 - bZIP transcription factor
PF03131 - bZIP Maf transcription factor
PF07716 - Basic region leucine zipper

SCOP Domains:
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain

ModBase Predicted Comparative 3D Structure on P13346
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007565 female pregnancy
GO:0009612 response to mechanical stimulus
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0042493 response to drug
GO:0043278 response to morphine
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051412 response to corticosterone
GO:0051591 response to cAMP
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF196098 - JP 2014500723-A/3601: Polycomb-Associated Non-Coding RNAs.
LF204619 - JP 2014500723-A/12122: Polycomb-Associated Non-Coding RNAs.
X14897 - Mouse fosB mRNA.
LF291357 - JP 2014500723-A/98860: Polycomb-Associated Non-Coding RNAs.
BC132064 - Mus musculus FBJ osteosarcoma oncogene B, mRNA (cDNA clone MGC:163695 IMAGE:40130341), complete cds.
BC137994 - Mus musculus FBJ osteosarcoma oncogene B, mRNA (cDNA clone MGC:169618 IMAGE:8861013), complete cds.
BC145082 - Mus musculus cDNA clone IMAGE:9053630.
LF291358 - JP 2014500723-A/98861: Polycomb-Associated Non-Coding RNAs.
AK171181 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630301H07 product:unclassifiable, full insert sequence.
LF291359 - JP 2014500723-A/98862: Polycomb-Associated Non-Coding RNAs.
AK154373 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630025E07 product:FBJ osteosarcoma oncogene B, full insert sequence.
MA431675 - JP 2018138019-A/3601: Polycomb-Associated Non-Coding RNAs.
MA440196 - JP 2018138019-A/12122: Polycomb-Associated Non-Coding RNAs.
MA526934 - JP 2018138019-A/98860: Polycomb-Associated Non-Coding RNAs.
MA526935 - JP 2018138019-A/98861: Polycomb-Associated Non-Coding RNAs.
MA526936 - JP 2018138019-A/98862: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04380 - Osteoclast differentiation

BioCarta from NCI Cancer Genome Anatomy Project
m_fosbPathway - FOSB gene expression and drug abuse

-  Other Names for This Gene
  Alternate Gene Symbols: FOSB_MOUSE, NM_008036, P13346, uc009flk.1, uc009flk.2
UCSC ID: uc009flk.2
RefSeq Accession: NM_008036
Protein: P13346 (aka FOSB_MOUSE)
CCDS: CCDS20897.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.