ID:CD79A_MOUSE DESCRIPTION: RecName: Full=B-cell antigen receptor complex-associated protein alpha chain; AltName: Full=Ig-alpha; AltName: Full=MB-1 membrane glycoprotein; AltName: Full=Membrane-bound immunoglobulin-associated protein; AltName: Full=Surface IgM-associated protein; AltName: CD_antigen=CD79a; Flags: Precursor; FUNCTION: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B-cells. SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-204, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. TISSUE SPECIFICITY: B-cells. PTM: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases, including LYN, is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation. PTM: Arginine methylation in the ITAM domain may interfere with the binding of SYK. It promotes signals leading to B cell differentiation. DISRUPTION PHENOTYPE: Mice display impaired B-cell development which does not progress pass the progenitor stage. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 ITAM domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11911
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04662 - B cell receptor signaling pathway mmu05340 - Primary immunodeficiency
BioCarta from NCI Cancer Genome Anatomy Project m_bcrmolecule - B Cell Receptor Complex m_bcrPathway - BCR Signaling Pathway m_ctcfPathway - CTCF: First Multivalent Nuclear Factor
Reactome (by CSHL, EBI, and GO)
Protein P11911 (Reactome details) participates in the following event(s):
R-MMU-983696 The Immunoglobulin of the BCR binds antigen R-MMU-983700 SYK binds the activated BCR R-MMU-5690740 CD22 binds B-cell receptor R-MMU-983707 SYK autophosphorylates at the activated BCR R-MMU-983703 p-6Y-SYK phosphorylates BLNK (SLP65) R-MMU-5690701 SHP1 binds p-CD22 R-MMU-5690702 LYN phosphorylates CD22 R-MMU-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-MMU-983705 Signaling by the B Cell Receptor (BCR) R-MMU-5690714 CD22 mediated BCR regulation R-MMU-1280218 Adaptive Immune System R-MMU-168256 Immune System
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