ID:ARHG1_MOUSE DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 1; AltName: Full=Lbc's second cousin; AltName: Full=Lymphoid blast crisis-like 2; FUNCTION: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity. SUBUNIT: Interacts with RHOA, GNA12 and GNA13 (By similarity). Homooligomerizes through the coiled coil region. Interacts with CTNNAL1 (By similarity). May interact with CCPG1. INTERACTION: Q64727:Vcl; NbExp=3; IntAct=EBI-641821, EBI-432047; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane (By similarity). Note=Translocated to the membrane by activated GNA13 or LPA stimulation (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for full GAP activity (By similarity). DOMAIN: The DH domain is involved in interaction with CCPG1. PTM: Phosphorylated by PKCA (By similarity). Angiotensin-2 induced Tyr-737 phosphorylation is mediated by JAK2. Isoform 5 is phosphorylated at 'Ser-390'. DISRUPTION PHENOTYPE: Mice have reduced response to angiotensin-2 and lowered RhoA signaling pathway. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 RGSL (RGS-like) domain. CAUTION: Ref.2 sequence was originally submitted as from rat origin.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q61210
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007186 G-protein coupled receptor signaling pathway GO:0035023 regulation of Rho protein signal transduction GO:0043547 positive regulation of GTPase activity GO:0060548 negative regulation of cell death