ID:LS14A_MOUSE DESCRIPTION: RecName: Full=Protein LSM14 homolog A; AltName: Full=Protein FAM61A; AltName: Full=RNA-associated protein 55A; Short=mRAP55A; FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs (By similarity). SUBUNIT: Component of a ribonucleoprotein (RNP) complex (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, P-body (By similarity). Note=Targeted to stress granules (SGs) in response to cellular stress (By similarity). DOMAIN: The LSM14 domain and the RGG repeats are required for accumulation in P-bodies, and the region containing the FDF motif is responsible for cytoplasmic retention (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the LSM14 family. SIMILARITY: Contains 1 DFDF domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8K2F8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006417 regulation of translation GO:0007275 multicellular organism development GO:0033962 cytoplasmic mRNA processing body assembly GO:0039529 RIG-I signaling pathway GO:0051607 defense response to virus GO:0060340 positive regulation of type I interferon-mediated signaling pathway