Mouse Gene Klk1b3 (ENSMUST00000085450.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus kallikrein 1-related peptidase b3 (Klk1b3), mRNA. (from RefSeq NM_008693) RefSeq Summary (NM_008693): This gene encodes the gamma subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. The encoded protein is a glandular kallikrein-type serine protease that processes the beta subunit of NGF. This gene is present in a cluster of multiple related kallikrein-type protease genes on chromosome 7. [provided by RefSeq, Jul 2015]. Gencode Transcript: ENSMUST00000085450.3 Gencode Gene: ENSMUSG00000066515.3 Transcript (Including UTRs) Position: mm10 chr7:44,198,191-44,202,352 Size: 4,162 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chr7:44,198,247-44,202,305 Size: 4,059 Coding Exon Count: 5
ID:K1KB3_MOUSE DESCRIPTION: RecName: Full=Kallikrein 1-related peptidase b3; EC=3.4.21.35; AltName: Full=7S nerve growth factor gamma chain; AltName: Full=Gamma-NGF; AltName: Full=Glandular kallikrein K3; Short=mGK-3; AltName: Full=Tissue kallikrein-3; Contains: RecName: Full=Nerve growth factor gamma chain 1; Contains: RecName: Full=Nerve growth factor gamma chain 2; Flags: Precursor; FUNCTION: 7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine- specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts. CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. COFACTOR: Binds 2 zinc ions per 7S complex. The zinc ions are bound at the alpha-gamma interfaces. SUBUNIT: 7S nerve growth factor is composed of two alpha chains, a beta dimer composed of identical chains, and two gamma chains. MISCELLANEOUS: This precursor is cleaved into segments to produce the active form of the gamma chain, which occurs naturally as combinations of either two or three segments held together by disulfide bonds: B1 and A, or B1, C and B2. SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily. SIMILARITY: Contains 1 peptidase S1 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P00756
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.