ID:NEUR3_MOUSE DESCRIPTION: RecName: Full=Sialidase-3; EC=3.2.1.18; AltName: Full=Ganglioside sialidase; AltName: Full=Membrane sialidase; AltName: Full=N-acetyl-alpha-neuraminidase 3; FUNCTION: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates (By similarity). CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain and cerebral cortex. SIMILARITY: Belongs to the glycosyl hydrolase 33 family. SIMILARITY: Contains 3 BNR repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9JMH7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006629 lipid metabolic process GO:0006689 ganglioside catabolic process GO:0008152 metabolic process GO:0009313 oligosaccharide catabolic process GO:0016042 lipid catabolic process
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00511 - Other glycan degradation mmu00600 - Sphingolipid metabolism
Reactome (by CSHL, EBI, and GO)
Protein Q9JMH7 (Reactome details) participates in the following event(s):
R-MMU-1605768 Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane) R-MMU-4084994 NEU3 hydrolyzes Neu5Ac from glycoconjugates R-MMU-1660662 Glycosphingolipid metabolism R-MMU-4085001 Sialic acid metabolism R-MMU-428157 Sphingolipid metabolism R-MMU-446219 Synthesis of substrates in N-glycan biosythesis R-MMU-556833 Metabolism of lipids R-MMU-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-MMU-1430728 Metabolism R-MMU-446203 Asparagine N-linked glycosylation R-MMU-597592 Post-translational protein modification R-MMU-392499 Metabolism of proteins