Mouse Gene Arap1 (ENSMUST00000084895.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (Arap1), transcript variant 1, mRNA. (from RefSeq NM_027180)
Gencode Transcript: ENSMUST00000084895.11
Gencode Gene: ENSMUSG00000032812.18
Transcript (Including UTRs)
Position: mm10 chr7:101,378,190-101,411,744 Size: 33,555 Total Exon Count: 31 Strand: +
Coding Region
Position: mm10 chr7:101,385,608-101,411,321 Size: 25,714 Coding Exon Count: 30
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ARAP1_MOUSE
DESCRIPTION: RecName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; AltName: Full=Centaurin-delta-2; Short=Cnt-d2;
FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).SUBUNIT: Interacts with TNFRSF10A (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus, Golgi stack membrane; Peripheral membrane protein (By similarity). Cell membrane (By similarity).SIMILARITY: Contains 1 Arf-GAP domain.SIMILARITY: Contains 4 PH domains.SIMILARITY: Contains 1 Ras-associating domain.SIMILARITY: Contains 1 Rho-GAP domain.SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR001164 - ArfGAP
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR000159 - Ras-assoc
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001660 - SAM
IPR013761 - SAM/pointed
IPR021129 - SAM_type1
Pfam Domains: PF00169 - PH domain
PF00620 - RhoGAP domain
PF00788 - Ras association (RalGDS/AF-6) domain
PF01412 - Putative GTPase activating protein for Arf
SCOP Domains: 48350 - GTPase activation domain, GAP
50729 - PH domain-like
54236 - Ubiquitin-like
48403 - Ankyrin repeat
57863 - ArfGap/RecO-like zinc finger
ModBase Predicted Comparative 3D Structure on Q4LDD4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK172210 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830106A05 product:centaurin, delta 2, full insert sequence.AK137455 - Mus musculus adult male bone cDNA, RIKEN full-length enriched library, clone:9830004A12 product:centaurin, delta 2, full insert sequence.AK140646 - Mus musculus 10 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:B930068K15 product:centaurin, delta 2, full insert sequence.BC141179 - Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, mRNA (cDNA clone MGC:176140 IMAGE:9055791), complete cds.AJ621558 - Mus musculus mRNA for ARAP1 (Centd2 gene).AK150132 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530135H12 product:centaurin, delta 2, full insert sequence.AK129213 - Mus musculus mRNA for mKIAA0782 protein.AK210757 - Mus musculus cDNA, clone:Y2G0119H19, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000067758, based on BLAT search.BC042640 - Mus musculus centaurin, delta 2, mRNA (cDNA clone IMAGE:5370033), with apparent retained intron.AK052437 - Mus musculus 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430022I02 product:SIMILAR TO CENTAURIN, DELTA 2 (FRAGMENT) homolog [Homo sapiens], full insert sequence.AK199434 - Mus musculus cDNA, clone:Y1G0131D08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000067758, based on BLAT search.BC057922 - Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, mRNA (cDNA clone IMAGE:5101122), partial cds.BC091762 - Mus musculus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, mRNA (cDNA clone IMAGE:5052745), partial cds.BC069849 - Mus musculus centaurin, delta 2, mRNA (cDNA clone IMAGE:5148694).AK010344 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410002L19 product:hypothetical protein, full insert sequence.BC083088 - Mus musculus cDNA clone IMAGE:30293394.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ARAP1_MOUSE, B2RUJ3, Centd2, Kiaa0782, NM_027180, Q3UDD2, Q3US99, Q4LDD4, Q58ET6, Q6PEQ9, Q6ZQ48, uc009iom.1, uc009iom.2UCSC ID: uc009iom.2RefSeq Accession: NM_001040112
Protein: Q4LDD4
(aka ARAP1_MOUSE)
CCDS: CCDS21510.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.