ID:ACSM1_MOUSE DESCRIPTION: RecName: Full=Acyl-coenzyme A synthetase ACSM1, mitochondrial; EC=6.2.1.2; AltName: Full=Acyl-CoA synthetase medium-chain family member 1; AltName: Full=Butyrate--CoA ligase 1; AltName: Full=Butyryl-coenzyme A synthetase 1; AltName: Full=Lipoate-activating enzyme; AltName: Full=Middle-chain acyl-CoA synthetase 1; Flags: Precursor; FUNCTION: Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity). Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). CATALYTIC ACTIVITY: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA. CATALYTIC ACTIVITY: GTP + lipoate = diphosphate + lipoyl-GMP. COFACTOR: Magnesium (By similarity). SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Highly expressed in liver and kidney. SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q91VA0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006637 acyl-CoA metabolic process GO:0008152 metabolic process
US Server
