Mouse Gene Mapk3 (ENSMUST00000091328.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt D3Z6D8)
Gencode Transcript: ENSMUST00000091328.3
Gencode Gene: ENSMUSG00000063065.13
Transcript (Including UTRs)
   Position: mm10 chr7:126,760,597-126,765,819 Size: 5,223 Total Exon Count: 8 Strand: +
Coding Region
   Position: mm10 chr7:126,760,903-126,764,845 Size: 3,943 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr7:126,760,597-126,765,819)mRNA (may differ from genome)Protein (265 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Mitogen-activated protein kinase 3;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -94.90306-0.310 Picture PostScript Text
3' UTR -225.00612-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR008349 - MAPK_ERK1/2
IPR000719 - Prot_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on D3Z6D8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002741 positive regulation of cytokine secretion involved in immune response
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0009887 animal organ morphogenesis
GO:0010759 positive regulation of macrophage chemotaxis
GO:0014032 neural crest cell development
GO:0019233 sensory perception of pain
GO:0030278 regulation of ossification
GO:0030641 regulation of cellular pH
GO:0030878 thyroid gland development
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0042473 outer ear morphogenesis
GO:0043330 response to exogenous dsRNA
GO:0048538 thymus development
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051216 cartilage development
GO:0060020 Bergmann glial cell differentiation
GO:0060324 face development
GO:0060425 lung morphogenesis
GO:0060440 trachea formation
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0070371 ERK1 and ERK2 cascade
GO:0071356 cellular response to tumor necrosis factor
GO:1904417 positive regulation of xenophagy
GO:1905050 positive regulation of metallopeptidase activity
GO:2000657 negative regulation of apolipoprotein binding

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031143 pseudopodium

-  Descriptions from all associated GenBank mRNAs
  BC029712 - Mus musculus mitogen-activated protein kinase 3, mRNA (cDNA clone MGC:31045 IMAGE:5041517), complete cds.
Z14249 - M.musculus mRNA for mitogen activated protein kinase (erk-1).
BC013754 - Mus musculus mitogen-activated protein kinase 3, mRNA (cDNA clone IMAGE:3597974), partial cds.
AK155287 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630215B22 product:mitogen activated protein kinase 3, full insert sequence.
X64605 - Mus musculus erk1 mRNA.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04012 - ErbB signaling pathway
mmu04062 - Chemokine signaling pathway
mmu04114 - Oocyte meiosis
mmu04150 - mTOR signaling pathway
mmu04270 - Vascular smooth muscle contraction
mmu04320 - Dorso-ventral axis formation
mmu04350 - TGF-beta signaling pathway
mmu04360 - Axon guidance
mmu04370 - VEGF signaling pathway
mmu04380 - Osteoclast differentiation
mmu04510 - Focal adhesion
mmu04520 - Adherens junction
mmu04540 - Gap junction
mmu04620 - Toll-like receptor signaling pathway
mmu04621 - NOD-like receptor signaling pathway
mmu04650 - Natural killer cell mediated cytotoxicity
mmu04660 - T cell receptor signaling pathway
mmu04662 - B cell receptor signaling pathway
mmu04664 - Fc epsilon RI signaling pathway
mmu04666 - Fc gamma R-mediated phagocytosis
mmu04720 - Long-term potentiation
mmu04722 - Neurotrophin signaling pathway
mmu04730 - Long-term depression
mmu04810 - Regulation of actin cytoskeleton
mmu04910 - Insulin signaling pathway
mmu04912 - GnRH signaling pathway
mmu04914 - Progesterone-mediated oocyte maturation
mmu04916 - Melanogenesis
mmu04930 - Type II diabetes mellitus
mmu04960 - Aldosterone-regulated sodium reabsorption
mmu05010 - Alzheimer's disease
mmu05020 - Prion diseases
mmu05140 - Leishmaniasis
mmu05142 - Chagas disease (American trypanosomiasis)
mmu05145 - Toxoplasmosis
mmu05160 - Hepatitis C
mmu05200 - Pathways in cancer
mmu05210 - Colorectal cancer
mmu05211 - Renal cell carcinoma
mmu05212 - Pancreatic cancer
mmu05213 - Endometrial cancer
mmu05214 - Glioma
mmu05215 - Prostate cancer
mmu05216 - Thyroid cancer
mmu05218 - Melanoma
mmu05219 - Bladder cancer
mmu05220 - Chronic myeloid leukemia
mmu05221 - Acute myeloid leukemia
mmu05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
m_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
m_CCR3Pathway - CCR3 signaling in Eosinophils
m_badPathway - Regulation of BAD phosphorylation
m_dspPathway - Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
m_erk5Pathway - Role of Erk5 in Neuronal Survival
m_il3Pathway - IL 3 signaling pathway
m_insulinPathway - Insulin Signaling Pathway
m_integrinPathway - Integrin Signaling Pathway
m_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
m_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
m_rasPathway - Ras Signaling Pathway
m_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
m_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
m_RacCycDPathway - Influence of Ras and Rho proteins on G1 to S Transition
m_TPOPathway - TPO Signaling Pathway
m_barr-mapkPathway - Role of -arrestins in the activation and targeting of MAP kinases
m_cdk5Pathway - Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
m_ceramidePathway - Ceramide Signaling Pathway
m_erkPathway - Erk1/Erk2 Mapk Signaling pathway
m_il2Pathway - IL 2 signaling pathway
m_bArrestin-srcPathway - Roles of -arrestin-dependent Recruitment of Src Kinases in GPCR Signaling
m_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
m_gpcrPathway - Signaling Pathway from G-Protein Families
m_mapkPathway - MAPKinase Signaling Pathway
m_pelp1Pathway - Pelp1 Modulation of Estrogen Receptor Activity
m_spryPathway - Sprouty regulation of tyrosine kinase signals
m_mPRPathway - How Progesterone Initiates the Oocyte Maturation
m_stat3Pathway - Stat3 Signaling Pathway
m_bcrPathway - BCR Signaling Pathway
m_crebPathway - Transcription factor CREB and its extracellular signals
m_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM
m_egfPathway - EGF Signaling Pathway
m_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
m_malPathway - Role of MAL in Rho-Mediated Activation of SRF
m_ngfPathway - Nerve growth factor pathway (NGF)
m_pdgfPathway - PDGF Signaling Pathway
m_tcrPathway - T Cell Receptor Signaling Pathway
m_edg1Pathway - Phospholipids as signalling intermediaries
m_epoPathway - EPO Signaling Pathway
m_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
m_keratinocytePathway - Keratinocyte Differentiation
m_pyk2Pathway - Links between Pyk2 and Map Kinases
m_cdMacPathway - Cadmium induces DNA synthesis and proliferation in macrophages
m_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
m_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
m_il6Pathway - IL 6 signaling pathway
m_sam68Pathway - Regulation of Splicing through Sam68
m_tffPathway - Trefoil Factors Initiate Mucosal Healing
m_ghPathway - Growth Hormone Signaling Pathway
m_agrPathway - Agrin in Postsynaptic Differentiation
m_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
m_cxcr4Pathway - CXCR4 Signaling Pathway
m_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
m_gleevecpathway - Inhibition of Cellular Proliferation by Gleevec
m_igf1Pathway - IGF-1 Signaling Pathway
m_metPathway - Signaling of Hepatocyte Growth Factor Receptor
m_nkcellsPathway - Ras-Independent pathway in NK cell-mediated cytotoxicity
m_tgfbPathway - TGF beta signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: AK155287, D3Z6D8, D3Z6D8_MOUSE, uc009jsn.1, uc009jsn.2
UCSC ID: uc009jsn.2
RefSeq Accession: NM_011952
Protein: D3Z6D8

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.