Mouse Gene Taok2 (ENSMUST00000117394.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus TAO kinase 2 (Taok2), transcript variant 2, mRNA. (from RefSeq NM_001163775)
Gencode Transcript: ENSMUST00000117394.1
Gencode Gene: ENSMUSG00000059981.12
Transcript (Including UTRs)
   Position: mm10 chr7:126,869,503-126,884,703 Size: 15,201 Total Exon Count: 16 Strand: -
Coding Region
   Position: mm10 chr7:126,869,932-126,880,628 Size: 10,697 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:126,869,503-126,884,703)mRNA (may differ from genome)Protein (1240 aa)
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-  Comments and Description Text from UniProtKB
  ID: TAOK2_MOUSE
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase TAO2; EC=2.7.11.1; AltName: Full=Thousand and one amino acid protein 2;
FUNCTION: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7- mediated activation of CHUK, and thus NF-kappa-B activation. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium (By similarity).
SUBUNIT: Interacts with MAP2K3 and MAP2K6 (By similarity). Self- associates. Interacts with tubulins. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation (By similarity). Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Found to be perinuclear and localized to vesicular compartment (By similarity).
SUBCELLULAR LOCATION: Isoform 2: Cell projection, dendrite (By similarity). Note=In dendrites, colocalizes with PCDH8 (By similarity).
PTM: Autophosphorylated. Isoform 2 is phosphorylated at 'Ser-1037' by MAPK14. This phosphorylation is required PCDH8 for endocytosis. Phosphorylated by ATM (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=AAH52933.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N- and C-terminal parts; Sequence=BAC98045.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -354.40833-0.425 Picture PostScript Text
3' UTR -101.63429-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
48371 - ARM repeat
56112 - Protein kinase-like (PK-like)
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q6ZQ29
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0038191 neuropilin binding

Biological Process:
GO:0000186 activation of MAPKK activity
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007346 regulation of mitotic cell cycle
GO:0007399 nervous system development
GO:0007409 axonogenesis
GO:0008360 regulation of cell shape
GO:0016310 phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032956 regulation of actin cytoskeleton organization
GO:0042981 regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0048041 focal adhesion assembly
GO:0051403 stress-activated MAPK cascade

Cellular Component:
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0015629 actin cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  AK129235 - Mus musculus mRNA for mKIAA0881 protein.
BC075676 - Mus musculus cDNA clone IMAGE:30548673, containing frame-shift errors.
BC085152 - Mus musculus TAO kinase 2, mRNA (cDNA clone IMAGE:6837633), with apparent retained intron.
BC077714 - Mus musculus TAO kinase 2, mRNA (cDNA clone IMAGE:30292251).
AK031190 - Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930425F14 product:Serine/threonine protein kinase TAO2 homolog [Rattus norvegicus], full insert sequence.
BC052933 - Mus musculus TAO kinase 2, mRNA (cDNA clone IMAGE:5056438), partial cds.
AK198039 - Mus musculus cDNA, clone:Y1G0126P03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000058496, based on BLAT search.
AK212532 - Mus musculus cDNA, clone:Y2G0125E10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000058496, based on BLAT search.
AK204257 - Mus musculus cDNA, clone:Y1G0147M07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000058496, based on BLAT search.
AK046145 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230344N16 product:unknown EST, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: Kiaa0881, NM_001163775, Q6ZQ29, Q7TSS8, TAOK2_MOUSE, uc009jth.1, uc009jth.2, uc009jth.3
UCSC ID: uc009jth.3
RefSeq Accession: NM_001163775
Protein: Q6ZQ29 (aka TAOK2_MOUSE)
CCDS: CCDS52403.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.