Mouse Gene Fgfr2 (ENSMUST00000117872.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. (from UniProt E9Q5C2)
Gencode Transcript: ENSMUST00000117872.7
Gencode Gene: ENSMUSG00000030849.18
Transcript (Including UTRs)
Position: mm10 chr7:130,162,512-130,266,245 Size: 103,734 Total Exon Count: 16 Strand: -
Coding Region
Position: mm10 chr7:130,163,959-130,261,914 Size: 97,956 Coding Exon Count: 15
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: E9Q5C2_MOUSE
DESCRIPTION: RecName: Full=Fibroblast growth factor receptor; EC=2.7.10.1;
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.SIMILARITY: Contains 1 protein kinase domain.CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003598 - Ig_sub2
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR016248 - Tyr_kinase_fibroblast_GF_rcpt
Pfam Domains: PF00047 - Immunoglobulin domain
PF00069 - Protein kinase domain
PF07679 - Immunoglobulin I-set domain
PF07714 - Protein tyrosine kinase
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain
SCOP Domains: 48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on E9Q5C2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK081810 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130078M18 product:fibroblast growth factor receptor 2, full insert sequence.BC091652 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:5349249), **** WARNING: chimeric clone ****.BC072640 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:30535919), **** WARNING: chimeric clone ****.BC065069 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:6836312), **** WARNING: chimeric clone ****.M63503 - Mouse keratinocyte growth factor receptor mRNA, complete cds.M86441 - M.musculus BEK FGF receptor mRNA, complete cds.BC151201 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone MGC:184100 IMAGE:9088089), complete cds.BC172174 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone MGC:198879 IMAGE:9054844), complete cds.M23362 - Mus musculus tyrosine kinase (bek) mRNA, 3' end.EF143322 - Mus musculus clone 1 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143323 - Mus musculus clone 2 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143324 - Mus musculus clone 3 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143325 - Mus musculus clone 4 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143326 - Mus musculus clone 5 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143327 - Mus musculus clone 6 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143328 - Mus musculus clone 7 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143329 - Mus musculus clone 8 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143330 - Mus musculus clone 9 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143331 - Mus musculus clone 10 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143332 - Mus musculus clone 11 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143333 - Mus musculus clone 12 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143334 - Mus musculus clone 13 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143335 - Mus musculus clone 14 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143336 - Mus musculus clone 15 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143337 - Mus musculus clone 16 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143338 - Mus musculus clone 17 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143339 - Mus musculus clone 18 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.EF143340 - Mus musculus clone 19 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.X55441 - Mouse bek genomic RNA for FGF-receptor.AK038588 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230048F11 product:fibroblast growth factor receptor 2, full insert sequence.AK051794 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130092I09 product:fibroblast growth factor receptor 2, full insert sequence.BC110661 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:4934818), **** WARNING: chimeric clone ****.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: BC065069, E9Q5C2, E9Q5C2_MOUSE, uc009jzv.1, uc009jzv.2UCSC ID: uc009jzv.2RefSeq Accession: NM_001347638
Protein: E9Q5C2
CCDS: CCDS85431.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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