Mouse Gene Fgfr2 (ENSMUST00000117872.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. (from UniProt E9Q5C2)
Gencode Transcript: ENSMUST00000117872.7
Gencode Gene: ENSMUSG00000030849.18
Transcript (Including UTRs)
   Position: mm10 chr7:130,162,512-130,266,245 Size: 103,734 Total Exon Count: 16 Strand: -
Coding Region
   Position: mm10 chr7:130,163,959-130,261,914 Size: 97,956 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:130,162,512-130,266,245)mRNA (may differ from genome)Protein (723 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
ReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9Q5C2_MOUSE
DESCRIPTION: RecName: Full=Fibroblast growth factor receptor; EC=2.7.10.1;
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
SIMILARITY: Contains 1 protein kinase domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -284.10604-0.470 Picture PostScript Text
3' UTR -375.101447-0.259 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003598 - Ig_sub2
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR016248 - Tyr_kinase_fibroblast_GF_rcpt

Pfam Domains:
PF00047 - Immunoglobulin domain
PF00069 - Protein kinase domain
PF07679 - Immunoglobulin I-set domain
PF07714 - Protein tyrosine kinase
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on E9Q5C2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK081810 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130078M18 product:fibroblast growth factor receptor 2, full insert sequence.
BC091652 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:5349249), **** WARNING: chimeric clone ****.
BC072640 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:30535919), **** WARNING: chimeric clone ****.
BC065069 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:6836312), **** WARNING: chimeric clone ****.
M63503 - Mouse keratinocyte growth factor receptor mRNA, complete cds.
M86441 - M.musculus BEK FGF receptor mRNA, complete cds.
BC151201 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone MGC:184100 IMAGE:9088089), complete cds.
BC172174 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone MGC:198879 IMAGE:9054844), complete cds.
M23362 - Mus musculus tyrosine kinase (bek) mRNA, 3' end.
EF143322 - Mus musculus clone 1 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143323 - Mus musculus clone 2 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143324 - Mus musculus clone 3 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143325 - Mus musculus clone 4 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143326 - Mus musculus clone 5 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143327 - Mus musculus clone 6 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143328 - Mus musculus clone 7 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143329 - Mus musculus clone 8 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143330 - Mus musculus clone 9 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143331 - Mus musculus clone 10 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143332 - Mus musculus clone 11 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143333 - Mus musculus clone 12 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143334 - Mus musculus clone 13 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143335 - Mus musculus clone 14 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143336 - Mus musculus clone 15 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143337 - Mus musculus clone 16 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143338 - Mus musculus clone 17 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143339 - Mus musculus clone 18 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
EF143340 - Mus musculus clone 19 FGFR2 (Fgfr2) mRNA, complete cds, alternatively spliced.
X55441 - Mouse bek genomic RNA for FGF-receptor.
AK038588 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230048F11 product:fibroblast growth factor receptor 2, full insert sequence.
AK051794 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130092I09 product:fibroblast growth factor receptor 2, full insert sequence.
BC110661 - Mus musculus fibroblast growth factor receptor 2, mRNA (cDNA clone IMAGE:4934818), **** WARNING: chimeric clone ****.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04144 - Endocytosis
mmu04810 - Regulation of actin cytoskeleton
mmu05200 - Pathways in cancer
mmu05215 - Prostate cancer

Reactome (by CSHL, EBI, and GO)

Protein E9Q5C2 (Reactome details) participates in the following event(s):

R-MMU-190408 Autocatalytic phosphorylation of FGFR2b
R-MMU-190413 Autocatalytic phosphorylation of FGFR2c
R-MMU-5654159 Activated FGFR2 binds PLCG1
R-MMU-5654399 Activated FGFR2 binds FRS2
R-MMU-5654404 Activated FGFR2 binds SHC1
R-MMU-5654603 Activated FGFR2 binds FRS3
R-MMU-5654157 p-4Y-PLCG1 dissociates from activated FGFR2
R-MMU-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-MMU-5654397 Activated FGFR2 phosphorylates FRS2
R-MMU-5654147 Activated FGFR2 phosphorylates PLCG1
R-MMU-5654562 Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
R-MMU-5654406 Activated FGFR2:p-SHC1 binds GRB2:SOS1
R-MMU-5654407 Activated FGFR2 phosphorylates SHC1
R-MMU-5654605 Activated FGFR2 phosphorylates FRS3
R-MMU-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-MMU-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-MMU-5654729 p-CBL:GRB2 binds p-FRS2:activated FGFR2
R-MMU-5654608 Activated FGFR2:p-FRS bind to PPTN11
R-MMU-5654615 Activated FGFR2:pFRS binds GRB2:SOS1
R-MMU-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-MMU-5654677 CBL ubiquitinates FRS2 and FGFR2
R-MMU-5654607 Activated FGFR2 phosphorylates PPTN11
R-MMU-5654402 Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
R-MMU-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654618 Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
R-MMU-5672965 RAS GEFs promote RAS nucleotide exchange
R-MMU-2316434 PI3K phosphorylates PIP2 to PIP3
R-MMU-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-MMU-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-190377 FGFR2b ligand binding and activation
R-MMU-190241 FGFR2 ligand binding and activation
R-MMU-5654221 Phospholipase C-mediated cascade; FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654738 Signaling by FGFR2
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654696 Downstream signaling of activated FGFR2
R-MMU-190236 Signaling by FGFR
R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
R-MMU-162582 Signal Transduction
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-5684996 MAPK1/MAPK3 signaling
R-MMU-109704 PI3K Cascade
R-MMU-9006925 Intracellular signaling by second messengers
R-MMU-199418 Negative regulation of the PI3K/AKT network
R-MMU-5683057 MAPK family signaling cascades
R-MMU-112399 IRS-mediated signalling
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-2428928 IRS-related events triggered by IGF1R
R-MMU-74752 Signaling by Insulin receptor
R-MMU-2428924 IGF1R signaling cascade
R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

-  Other Names for This Gene
  Alternate Gene Symbols: BC065069, E9Q5C2, E9Q5C2_MOUSE, uc009jzv.1, uc009jzv.2
UCSC ID: uc009jzv.2
RefSeq Accession: NM_001347638
Protein: E9Q5C2 CCDS: CCDS85431.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.