ID:FGF4_MOUSE DESCRIPTION: RecName: Full=Fibroblast growth factor 4; Short=FGF-4; AltName: Full=Heparin-binding growth factor 4; Short=HBGF-4; AltName: Full=K-fibroblast growth factor; Flags: Precursor; FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis. SUBUNIT: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity). SUBCELLULAR LOCATION: Secreted (Potential). TISSUE SPECIFICITY: Expressed in the blastocyst inner cell mass and later in distinct embryonic tissues. SIMILARITY: Belongs to the heparin-binding growth factors family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P11403
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
