ID:I23O2_MOUSE DESCRIPTION: RecName: Full=Indoleamine 2,3-dioxygenase 2; Short=IDO-2; EC=1.13.11.-; AltName: Full=Indoleamine 2,3-dioxygenase-like protein 1; AltName: Full=Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; FUNCTION: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. CATALYTIC ACTIVITY: L-tryptophan + O(2) = N-formyl-L-kynurenine. COFACTOR: Binds 1 heme group per subunit (By similarity). ENZYME REGULATION: Activity is inhibited by D-1MT (1-methyl-D- tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan) (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=38.85 mM for L-tryptophan; Note=Do not accept D-tryptophan as substrate; PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. TISSUE SPECIFICITY: Highest in kidney, followed by epididymis and liver (at protein level). Detected in the tails of the spermatozoa in the testis and in the kidney tubules (at protein level). SIMILARITY: Belongs to the indoleamine 2,3-dioxygenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8R0V5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0006569 tryptophan catabolic process GO:0019441 tryptophan catabolic process to kynurenine GO:0055114 oxidation-reduction process
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