Mouse Gene Crlf1 (ENSMUST00000008032.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus cytokine receptor-like factor 1 (Crlf1), mRNA. (from RefSeq NM_018827) RefSeq Summary (NM_018827): This gene encodes a member of the cytokine type I receptor family. The encoded protein functions as a cytokine receptor subunit and may be involved in immune system regulation and fetal development. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENSMUST00000008032.13 Gencode Gene: ENSMUSG00000007888.15 Transcript (Including UTRs) Position: mm10 chr8:70,493,158-70,504,081 Size: 10,924 Total Exon Count: 9 Strand: + Coding Region Position: mm10 chr8:70,493,277-70,503,834 Size: 10,558 Coding Exon Count: 9
ID:CRLF1_MOUSE DESCRIPTION: RecName: Full=Cytokine receptor-like factor 1; AltName: Full=Cytokine receptor-like molecule 3; Short=CRLM-3; AltName: Full=Cytokine-like factor 1; Short=CLF-1; AltName: Full=Novel cytokine receptor 6; Short=NR6; Flags: Precursor; FUNCTION: Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development (By similarity). Plays an essential role in the initiation and/or maintenance of suckling in neonatal mice. SUBUNIT: Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR) (By similarity). SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Widely expressed in the embryo. Not detected in the brain of adult mice. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. SIMILARITY: Belongs to the type I cytokine receptor family. Type 3 subfamily. SIMILARITY: Contains 2 fibronectin type-III domains. SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48726 - Immunoglobulin 49363 - Purple acid phosphatase, N-terminal domain 49265 - Fibronectin type III
ModBase Predicted Comparative 3D Structure on Q9JM58
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001657 ureteric bud development GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043524 negative regulation of neuron apoptotic process GO:2000672 negative regulation of motor neuron apoptotic process
US Server
