Mouse Gene Insl3 (ENSMUST00000034261.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus insulin-like 3 (Insl3), mRNA. (from RefSeq NM_013564)
Gencode Transcript: ENSMUST00000034261.7
Gencode Gene: ENSMUSG00000079019.2
Transcript (Including UTRs)
   Position: mm10 chr8:71,689,214-71,690,575 Size: 1,362 Total Exon Count: 2 Strand: +
Coding Region
   Position: mm10 chr8:71,689,258-71,690,365 Size: 1,108 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:71,689,214-71,690,575)mRNA (may differ from genome)Protein (122 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q5RL10_MOUSE
DESCRIPTION: SubName: Full=Insulin-like 3; SubName: Full=MCG10367, isoform CRA_a;
SUBCELLULAR LOCATION: Secreted (By similarity).
SIMILARITY: Belongs to the insulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.2044-0.391 Picture PostScript Text
3' UTR -61.10210-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016179 - Insulin-like
IPR022353 - Insulin_CS
IPR022352 - Insulin_family

Pfam Domains:
PF00049 - Insulin/IGF/Relaxin family

SCOP Domains:
56994 - Insulin-like

ModBase Predicted Comparative 3D Structure on Q5RL10
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001664 G-protein coupled receptor binding
GO:0005179 hormone activity

Biological Process:
GO:0001556 oocyte maturation
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010469 regulation of receptor activity
GO:0043066 negative regulation of apoptotic process
GO:0043950 positive regulation of cAMP-mediated signaling

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK088365 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430014A10 product:Janus kinase 3, full insert sequence.
BC131646 - Mus musculus Janus kinase 3, mRNA (cDNA clone MGC:150120 IMAGE:40110146), complete cds.
BC131647 - Mus musculus Janus kinase 3, mRNA (cDNA clone MGC:150121 IMAGE:40110148), complete cds.
AK038268 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130091E14 product:Janus kinase 3, full insert sequence.
BC105577 - Mus musculus Janus kinase 3, mRNA (cDNA clone MGC:106030 IMAGE:3968386), complete cds.
L32955 - Mouse protein tyrosine kinase (jak3) mRNA, complete cds.
L33768 - Mus musculus (clone 32D5-1) protein tyrosine kinase (JAK3) mRNA.
LF202826 - JP 2014500723-A/10329: Polycomb-Associated Non-Coding RNAs.
AK132857 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930445A02 product:insulin-like 3, full insert sequence.
BC049540 - Mus musculus insulin-like 3, mRNA (cDNA clone MGC:58101 IMAGE:6773462), complete cds.
S82815 - RLF=relaxin-like factor/insulin homolog [mice, w/wv, testes, mRNA Partial Mutant, 585 nt].
MA438403 - JP 2018138019-A/10329: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5RL10 (Reactome details) participates in the following event(s):

R-MMU-444879 Relaxin receptor 2 binds relaxin 2 and INSL3
R-MMU-744886 The Ligand:GPCR:Gs complex dissociates
R-MMU-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-MMU-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-MMU-444821 Relaxin receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-388396 GPCR downstream signalling
R-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-372790 Signaling by GPCR
R-MMU-500792 GPCR ligand binding
R-MMU-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_10367, NM_013564, Q5RL10, Q5RL10_MOUSE, uc009meq.1, uc009meq.2, uc009meq.3
UCSC ID: uc009meq.3
RefSeq Accession: NM_013564
Protein: Q5RL10 CCDS: CCDS22404.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.