Mouse Gene Gab1 (ENSMUST00000034150.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus growth factor receptor bound protein 2-associated protein 1 (Gab1), transcript variant 2, mRNA. (from RefSeq NM_021356)
Gencode Transcript: ENSMUST00000034150.9
Gencode Gene: ENSMUSG00000031714.9
Transcript (Including UTRs)
   Position: mm10 chr8:80,764,440-80,880,496 Size: 116,057 Total Exon Count: 10 Strand: -
Coding Region
   Position: mm10 chr8:80,766,329-80,879,603 Size: 113,275 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:80,764,440-80,880,496)mRNA (may differ from genome)Protein (695 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GAB1_MOUSE
DESCRIPTION: RecName: Full=GRB2-associated-binding protein 1; AltName: Full=GRB2-associated binder 1; AltName: Full=Growth factor receptor bound protein 2-associated protein 1;
FUNCTION: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) (By similarity).
SUBUNIT: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ (By similarity). Interacts (phosphorylated) with PTPN11. Interacts with HCK (By similarity). Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1.
INTERACTION: Q60631:Grb2; NbExp=5; IntAct=EBI-644784, EBI-1688;
PTM: Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling (By similarity). Phosphorylated in response to FGFR1 activation.
SIMILARITY: Belongs to the GAB family.
SIMILARITY: Contains 1 PH domain.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • C006780 bisphenol A
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • C014024 2,4,5,2',4',5'-hexachlorobiphenyl
  • C023514 2,6-dinitrotoluene
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • D000082 Acetaminophen
  • D000393 Air Pollutants
          more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -445.80893-0.499 Picture PostScript Text
3' UTR -534.811889-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q9QYY0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0005515 protein binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0006979 response to oxidative stress
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0007507 heart development
GO:0008544 epidermis development
GO:0030334 regulation of cell migration
GO:0031532 actin cytoskeleton reorganization
GO:0035728 response to hepatocyte growth factor
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045766 positive regulation of angiogenesis
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0060711 labyrinthine layer development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0090668 endothelial cell chemotaxis to vascular endothelial growth factor

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  BC094659 - Mus musculus growth factor receptor bound protein 2-associated protein 1, mRNA (cDNA clone MGC:102051 IMAGE:6854020), complete cds.
BC007483 - Mus musculus growth factor receptor bound protein 2-associated protein 1, mRNA (cDNA clone MGC:7657 IMAGE:3495926), complete cds.
AK132176 - Mus musculus 17 days embryo head cDNA, RIKEN full-length enriched library, clone:3321404B21 product:growth factor receptor bound protein 2-associated protein 1, full insert sequence.
AK155423 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630226D05 product:growth factor receptor bound protein 2-associated protein 1, full insert sequence.
AJ250669 - Mus musculus gab1 gene for GRB2-associated binding protein 1.
CT010264 - Mus musculus full open reading frame cDNA clone RZPDo836F0451D for gene Gab1, RIKEN cDNA 1700019H22 gene; complete cds, incl. stopcodon.
DQ699390 - Mus musculus piRNA piR-114712, complete sequence.
BC057181 - Mus musculus cDNA clone IMAGE:5038990, partial cds.
AK050935 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030040M07 product:growth factor receptor bound protein 2-associated protein 1, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04012 - ErbB signaling pathway
mmu04722 - Neurotrophin signaling pathway
mmu05100 - Bacterial invasion of epithelial cells
mmu05211 - Renal cell carcinoma

BioCarta from NCI Cancer Genome Anatomy Project
m_metPathway - Signaling of Hepatocyte Growth Factor Receptor

Reactome (by CSHL, EBI, and GO)

Protein Q9QYY0 (Reactome details) participates in the following event(s):

R-MMU-177920 Binding of GRB2 to GAB1
R-MMU-8851908 Activated MET binds GAB1
R-MMU-8851919 Activated MET binds GAB1 and GRB2
R-MMU-177931 Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
R-MMU-179467 GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
R-MMU-1306963 Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
R-MMU-5654592 Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1
R-MMU-5654594 Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-MMU-5654612 Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
R-MMU-5654620 Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-MMU-5654637 Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
R-MMU-5654641 Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-MMU-5654659 Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1
R-MMU-5654667 Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
R-MMU-1306965 Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
R-MMU-177941 GRB2:GAB1 binds to phosphorylated EGFR
R-MMU-8851933 MET phosphorylates GAB1
R-MMU-8851954 Phosphorylated GAB1 recruits PI3K to MET
R-MMU-8865994 GAB1 binds PTPN11
R-MMU-8875540 GAB1 recruits CRK,CRKL to MET
R-MMU-8855508 p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11
R-MMU-5654591 Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-MMU-5654614 Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-MMU-5654640 Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-MMU-5654662 Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
R-MMU-5654596 Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-MMU-5654622 Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-MMU-5654643 Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
R-MMU-5654669 Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
R-MMU-177930 GAB1 phosphorylation by EGFR kinase
R-MMU-177927 PI3K binds to EGF:EGFR:GRB2:GAB1
R-MMU-177944 Activation of SHP2 through the binding to phospho-Gab1
R-MMU-177935 SHP2 dephosphorylates Tyr 992 on EGFR
R-MMU-8875558 RAPGEF1 binds CRK,CRKL
R-MMU-177924 Dephosphorylation of Gab1 by SHP2
R-MMU-109699 PI3K-containing complexes phosphorylate PIP2 to PIP3
R-MMU-8852019 MET bound PI3K generates PIP3
R-MMU-5654690 FGFR1-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654701 FGFR2-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654705 FGFR3-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654717 FGFR4-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654692 FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654697 FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654709 FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-5654714 FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
R-MMU-1306957 PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
R-MMU-177923 Sustained activation of SRC kinase by SHP2
R-MMU-177926 Dephosphorylation of PAG by SHP2
R-MMU-177939 PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
R-MMU-2316434 PI3K phosphorylates PIP2 to PIP3
R-MMU-8875568 RAPGEF1 activates RAP1
R-MMU-180292 GAB1 signalosome
R-MMU-8851907 MET activates PI3K/AKT signaling
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-8853659 RET signaling
R-MMU-177929 Signaling by EGFR
R-MMU-6806834 Signaling by MET
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654696 Downstream signaling of activated FGFR2
R-MMU-5654708 Downstream signaling of activated FGFR3
R-MMU-5654716 Downstream signaling of activated FGFR4
R-MMU-1227986 Signaling by ERBB2
R-MMU-422475 Axon guidance
R-MMU-9006934 Signaling by Receptor Tyrosine Kinases
R-MMU-8865999 MET activates PTPN11
R-MMU-8875555 MET activates RAP1 and RAC1
R-MMU-5654736 Signaling by FGFR1
R-MMU-5654738 Signaling by FGFR2
R-MMU-5654741 Signaling by FGFR3
R-MMU-5654743 Signaling by FGFR4
R-MMU-1266738 Developmental Biology
R-MMU-162582 Signal Transduction
R-MMU-8875656 MET receptor recycling
R-MMU-8875878 MET promotes cell motility
R-MMU-109704 PI3K Cascade
R-MMU-190236 Signaling by FGFR
R-MMU-112399 IRS-mediated signalling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-9032759 NTRK2 activates RAC1
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-2428928 IRS-related events triggered by IGF1R
R-MMU-9006925 Intracellular signaling by second messengers
R-MMU-199418 Negative regulation of the PI3K/AKT network
R-MMU-9032500 Activated NTRK2 signals through FYN
R-MMU-74752 Signaling by Insulin receptor
R-MMU-2428924 IGF1R signaling cascade
R-MMU-9006115 Signaling by NTRK2 (TRKB)
R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-MMU-166520 Signaling by NTRKs

-  Other Names for This Gene
  Alternate Gene Symbols: GAB1_MOUSE, NM_021356, Q91VW7, Q9QYY0, uc009mjb.1, uc009mjb.2, uc009mjb.3
UCSC ID: uc009mjb.3
RefSeq Accession: NM_001301298
Protein: Q9QYY0 (aka GAB1_MOUSE)
CCDS: CCDS22443.1, CCDS85569.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.