Mouse Gene Cpne2 (ENSMUST00000048653.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus copine II (Cpne2), mRNA. (from RefSeq NM_153507)
RefSeq Summary (NM_153507): Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENSMUST00000048653.9
Gencode Gene: ENSMUSG00000034361.10
Transcript (Including UTRs)
   Position: mm10 chr8:94,532,990-94,570,531 Size: 37,542 Total Exon Count: 16 Strand: +
Coding Region
   Position: mm10 chr8:94,548,366-94,570,078 Size: 21,713 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:94,532,990-94,570,531)mRNA (may differ from genome)Protein (548 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CPNE2_MOUSE
DESCRIPTION: RecName: Full=Copine-2; AltName: Full=Copine II;
SIMILARITY: Belongs to the copine family.
SIMILARITY: Contains 2 C2 domains.
SIMILARITY: Contains 1 VWFA domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.90242-0.524 Picture PostScript Text
3' UTR -96.70453-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR018029 - C2_membr_targeting
IPR010734 - Copine
IPR002035 - VWF_A

Pfam Domains:
PF00168 - C2 domain
PF07002 - Copine

SCOP Domains:
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
53300 - vWA-like

ModBase Predicted Comparative 3D Structure on P59108
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0071277 cellular response to calcium ion

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045334 clathrin-coated endocytic vesicle


-  Descriptions from all associated GenBank mRNAs
  BC031801 - Mus musculus copine II, mRNA (cDNA clone MGC:30751 IMAGE:3985959), complete cds.
AK160238 - Mus musculus 17 days embryo head cDNA, RIKEN full-length enriched library, clone:3322401K10 product:copine II, full insert sequence.
AK086165 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:D930009E14 product:weakly similar to COPINE III [Homo sapiens], full insert sequence.
BC022128 - Mus musculus copine II, mRNA (cDNA clone MGC:37787 IMAGE:5097527), complete cds.
BC023348 - Mus musculus copine II, mRNA (cDNA clone MGC:32287 IMAGE:5012573), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CPNE2_MOUSE, NM_153507, P59108, Q8K1D7, uc009mwm.1, uc009mwm.2
UCSC ID: uc009mwm.2
RefSeq Accession: NM_153507
Protein: P59108 (aka CPNE2_MOUSE or CNE2_MOUSE)
CCDS: CCDS22543.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.