ID:GBRL2_MOUSE DESCRIPTION: RecName: Full=Gamma-aminobutyric acid receptor-associated protein-like 2; AltName: Full=GABA(A) receptor-associated protein-like 2; AltName: Full=Golgi-associated ATPase enhancer of 16 kDa; Short=GATE-16; FUNCTION: Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). SUBUNIT: Monomer. Interacts with GABRG2, ULK1, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D25. SUBCELLULAR LOCATION: Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome (By similarity). TISSUE SPECIFICITY: Ubiquitous. A high level expression is seen in brain, thymus, lung, heart, liver and kidney. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). SIMILARITY: Belongs to the MAP1 LC3 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P60521
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding
Biological Process: GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0006891 intra-Golgi vesicle-mediated transport GO:0006914 autophagy GO:0006995 cellular response to nitrogen starvation GO:0015031 protein transport GO:1901799 negative regulation of proteasomal protein catabolic process
US Server
