ID:GAN_MOUSE DESCRIPTION: RecName: Full=Gigaxonin; FUNCTION: Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Expressed in brain, heart and muscle (at protein level). PTM: Ubiquitinated and probably targeted for proteasome- independent degradation (By similarity). DISRUPTION PHENOTYPE: Mice have a relatively normal life span. However, they display deterioration in motor function with onset varying from 6 to 10 months as well as abnormalities in non- neuronal tissues. The prominent pathological features include limb weakness, muscular atrophy, axonal degeneration, neurofilament accumulation, an abnormal microtubule network, mitochondrial swelling and thinned myelin sheaths. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 6 Kelch repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8CA72
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q8CA72 (Reactome details) participates in the following event(s):
R-MMU-983157 Interaction of E3 with substrate and E2-Ub complex R-MMU-983147 Release of E3 from polyubiquitinated substrate R-MMU-983140 Transfer of Ub from E2 to substrate and release of E2 R-MMU-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-MMU-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-MMU-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation R-MMU-983169 Class I MHC mediated antigen processing & presentation R-MMU-8951664 Neddylation R-MMU-1280218 Adaptive Immune System R-MMU-597592 Post-translational protein modification R-MMU-168256 Immune System R-MMU-392499 Metabolism of proteins
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