Mouse Gene Irf8 (ENSMUST00000047737.9) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus interferon regulatory factor 8 (Irf8), transcript variant 2, mRNA. (from RefSeq NM_008320) RefSeq Summary (NM_008320): The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Gencode Transcript: ENSMUST00000047737.9 Gencode Gene: ENSMUSG00000041515.10 Transcript (Including UTRs) Position: mm10 chr8:120,736,358-120,756,694 Size: 20,337 Total Exon Count: 9 Strand: + Coding Region Position: mm10 chr8:120,739,818-120,755,175 Size: 15,358 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q544J7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006909 phagocytosis GO:0006955 immune response GO:0009617 response to bacterium GO:0030099 myeloid cell differentiation GO:0032729 positive regulation of interferon-gamma production GO:0032735 positive regulation of interleukin-12 production GO:0042742 defense response to bacterium GO:0042832 defense response to protozoan GO:0044130 negative regulation of growth of symbiont in host GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter GO:0071222 cellular response to lipopolysaccharide GO:0071346 cellular response to interferon-gamma
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