ID:DPEP1_MOUSE DESCRIPTION: RecName: Full=Dipeptidase 1; EC=3.4.13.19; AltName: Full=Membrane-bound dipeptidase 1; Short=MBD-1; AltName: Full=Microsomal dipeptidase; AltName: Full=Renal dipeptidase; Flags: Precursor; FUNCTION: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. CATALYTIC ACTIVITY: Hydrolysis of dipeptides. COFACTOR: Zinc. ENZYME REGULATION: Inhibited by L-penicillamine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10 uM for leukotriene D4; KM=0.45 mM for cystinyl-bis-glycine; KM=111 uM for beta-lactam; SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane. SIMILARITY: Belongs to the peptidase M19 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31428
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008233 peptidase activity GO:0008235 metalloexopeptidase activity GO:0008237 metallopeptidase activity GO:0008239 dipeptidyl-peptidase activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016805 dipeptidase activity GO:0034235 GPI anchor binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0046872 metal ion binding GO:0070573 metallodipeptidase activity GO:0072341 modified amino acid binding
Biological Process: GO:0006508 proteolysis GO:0006915 apoptotic process GO:0016999 antibiotic metabolic process GO:0030336 negative regulation of cell migration GO:0035690 cellular response to drug GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0050667 homocysteine metabolic process GO:0071277 cellular response to calcium ion GO:0071732 cellular response to nitric oxide
US Server
