ID:PTPS_MOUSE DESCRIPTION: RecName: Full=6-pyruvoyl tetrahydrobiopterin synthase; Short=PTP synthase; Short=PTPS; EC=4.2.3.12; FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin. CATALYTIC ACTIVITY: 7,8-dihydroneopterin 3'-triphosphate = 6- pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate. COFACTOR: Binds 1 zinc ion per subunit (By similarity). PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3. SUBUNIT: Homohexamer formed of two homotrimers in a head to head fashion (By similarity). PTM: Phosphorylation of Ser-18 is required for maximal enzyme activity (By similarity). MISCELLANEOUS: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit. SIMILARITY: Belongs to the PTPS family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9R1Z7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00790 - Folate biosynthesis mmu01100 - Metabolic pathways
BioCyc Knowledge Library PWY-5663 - tetrahydrobiopterin biosynthesis I PWY-5664 - tetrahydrobiopterin biosynthesis II
Reactome (by CSHL, EBI, and GO)
Protein Q9R1Z7 (Reactome details) participates in the following event(s):
R-MMU-1475422 PTPS is phosphorylated by cGMP-dependant protein kinase II R-MMU-1474184 DHNTP is dephosphorylated by PTPS to PTHP R-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-MMU-8978934 Metabolism of cofactors R-MMU-196854 Metabolism of vitamins and cofactors R-MMU-1430728 Metabolism