Mouse Gene Pts (ENSMUST00000034570.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus 6-pyruvoyl-tetrahydropterin synthase (Pts), transcript variant 1, mRNA. (from RefSeq NM_011220)
Gencode Transcript: ENSMUST00000034570.6
Gencode Gene: ENSMUSG00000032067.6
Transcript (Including UTRs)
   Position: mm10 chr9:50,521,617-50,528,651 Size: 7,035 Total Exon Count: 6 Strand: -
Coding Region
   Position: mm10 chr9:50,522,213-50,528,636 Size: 6,424 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:50,521,617-50,528,651)mRNA (may differ from genome)Protein (144 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PTPS_MOUSE
DESCRIPTION: RecName: Full=6-pyruvoyl tetrahydrobiopterin synthase; Short=PTP synthase; Short=PTPS; EC=4.2.3.12;
FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin.
CATALYTIC ACTIVITY: 7,8-dihydroneopterin 3'-triphosphate = 6- pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
SUBUNIT: Homohexamer formed of two homotrimers in a head to head fashion (By similarity).
PTM: Phosphorylation of Ser-18 is required for maximal enzyme activity (By similarity).
MISCELLANEOUS: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.
SIMILARITY: Belongs to the PTPS family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -152.80596-0.256 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007115 - 6-PTP_synth/QueD
IPR022470 - PTPS_Cys_AS
IPR022469 - PTPS_His_AS

Pfam Domains:
PF01242 - 6-pyruvoyl tetrahydropterin synthase

SCOP Domains:
50324 - Inorganic pyrophosphatase
55620 - Tetrahydrobiopterin biosynthesis enzymes-like

ModBase Predicted Comparative 3D Structure on Q9R1Z7
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsemblWormBase 
Protein SequenceProtein Sequence Protein SequenceProtein Sequence 
AlignmentAlignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003874 6-pyruvoyltetrahydropterin synthase activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0006729 tetrahydrobiopterin biosynthetic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  LF197584 - JP 2014500723-A/5087: Polycomb-Associated Non-Coding RNAs.
BC019660 - Mus musculus cDNA clone IMAGE:4500975.
BC029013 - Mus musculus 6-pyruvoyl-tetrahydropterin synthase, mRNA (cDNA clone MGC:36014 IMAGE:5357873), complete cds.
AK002614 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610012K15 product:6-pyruvoyl-tetrahydropterin synthase, full insert sequence.
AK146987 - Mus musculus 17 days embryo stomach cDNA, RIKEN full-length enriched library, clone:I920082H04 product:6-pyruvoyl-tetrahydropterin synthase, full insert sequence.
AK153959 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430014C24 product:6-pyruvoyl-tetrahydropterin synthase, full insert sequence.
AF043225 - Mus musculus 6-pyruvoyl-tetrahydropterin synthase (Pts) mRNA, complete cds.
AK160842 - Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:3526402B21 product:hypothetical protein, full insert sequence.
MA433161 - JP 2018138019-A/5087: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00790 - Folate biosynthesis
mmu01100 - Metabolic pathways

BioCyc Knowledge Library
PWY-5663 - tetrahydrobiopterin biosynthesis I
PWY-5664 - tetrahydrobiopterin biosynthesis II

Reactome (by CSHL, EBI, and GO)

Protein Q9R1Z7 (Reactome details) participates in the following event(s):

R-MMU-1475422 PTPS is phosphorylated by cGMP-dependant protein kinase II
R-MMU-1474184 DHNTP is dephosphorylated by PTPS to PTHP
R-MMU-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-MMU-8978934 Metabolism of cofactors
R-MMU-196854 Metabolism of vitamins and cofactors
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NM_011220, PTPS_MOUSE, Q3UIB6, Q9R1Z7, Q9Z2N2, uc009pjp.1, uc009pjp.2
UCSC ID: uc009pjp.2
RefSeq Accession: NM_011220
Protein: Q9R1Z7 (aka PTPS_MOUSE)
CCDS: CCDS23164.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.