ID:OBF1_MOUSE DESCRIPTION: RecName: Full=POU domain class 2-associating factor 1; AltName: Full=B-cell-specific coactivator OBF-1; AltName: Full=BOB-1; Short=BOB1; AltName: Full=OCA-B; AltName: Full=OCT-binding factor 1; FUNCTION: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. INTERACTION: P48025:Syk; NbExp=2; IntAct=EBI-943530, EBI-300116; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: B-cell specific. PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity). SIMILARITY: Belongs to the POU2AF1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09310 - POU domain, class 2, associating factor 1
ModBase Predicted Comparative 3D Structure on Q64693
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0001105 RNA polymerase II transcription coactivator activity GO:0003677 DNA binding GO:0005515 protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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