ID:EDC3_MOUSE DESCRIPTION: RecName: Full=Enhancer of mRNA-decapping protein 3; AltName: Full=YjeF domain-containing protein 1; FUNCTION: Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping (By similarity). SUBUNIT: Homodimer (via YjeF N-terminal domain). Forms a complex with DCP1A, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with DCP1A and DDX6. Interacts with ZFP36 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, P-body (By similarity). Note=Processing bodies (PB) (By similarity). DOMAIN: The DFDF domain is unstructured by itself. It assumes a helical fold upon interaction with DDX6 (By similarity). SIMILARITY: Belongs to the EDC3 family. SIMILARITY: Contains 1 DFDF domain. SIMILARITY: Contains 1 YjeF N-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03853 - YjeF-related protein N-terminus PF09532 - FDF domain PF12701 - Scd6-like Sm domain PF16598 - Linker region of enhancer of mRNA-decapping protein 3
ModBase Predicted Comparative 3D Structure on Q8K2D3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
