ID:ARI3B_MOUSE DESCRIPTION: RecName: Full=AT-rich interactive domain-containing protein 3B; Short=ARID domain-containing protein 3B; AltName: Full=Bright and dead ringer protein; AltName: Full=Bright-like protein; FUNCTION: Transcription factor involved in the production of cranial mesenchymal tissues. Favors nuclear targeting of ARID3A. SUBUNIT: Heterodimer with ARID3A. Interacts with unphosphorylated RB1 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed at high levels in testis. Also expressed in prostate, thyroid and thymus. DEVELOPMENTAL STAGE: First detected at E7. Strongly expressed in cranial mesenchyme and caudal mesoderm. Expression in cranial mesenchyme decreases starting from E10.5. DISRUPTION PHENOTYPE: Embryos die before E11.5 and display various abnormalities, including wavy neural tube, small branchial arches and defects of cardiovascular system. SIMILARITY: Contains 1 ARID domain. SIMILARITY: Contains 1 REKLES domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Z1N7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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