Mouse Gene Nptn (ENSMUST00000176250.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). (from UniProt P97300) Gencode Transcript: ENSMUST00000176250.1 Gencode Gene: ENSMUSG00000032336.17 Transcript (Including UTRs) Position: mm10 chr9:58,629,106-58,655,208 Size: 26,103 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chr9:58,629,231-58,651,318 Size: 22,088 Coding Exon Count: 5
ID:NPTN_MOUSE DESCRIPTION: RecName: Full=Neuroplastin; AltName: Full=Stromal cell-derived receptor 1; Short=SDR-1; Flags: Precursor; FUNCTION: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). Note=Enriched at postsynaptic density (By similarity). TISSUE SPECIFICITY: Isoform 1 and isoform 2 are widely expressed with variable levels in brain. Isoform 1 is expressed in cerebellum and midbrain. Isoform 1 and isoform 2 are expressed in cerebral cortex, hipoccampus and striatum. Isoform 2 is more abundant in the cerebral cortex than isoform 1. DOMAIN: Some isoforms lack the first Ig-like domain which may confer homophilic adhesion activity. However, they can bind and activate FGFR1 (By similarity). PTM: N-glycosylated (By similarity). SIMILARITY: Contains 3 Ig-like (immunoglobulin-like) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P97300
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
