Mouse Gene Pias1 (ENSMUST00000098651.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus protein inhibitor of activated STAT 1 (Pias1), mRNA. (from RefSeq NM_019663)
Gencode Transcript: ENSMUST00000098651.5
Gencode Gene: ENSMUSG00000032405.10
Transcript (Including UTRs)
   Position: mm10 chr9:62,878,368-62,980,879 Size: 102,512 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm10 chr9:62,881,968-62,980,871 Size: 98,904 Coding Exon Count: 14 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:62,878,368-62,980,879)mRNA (may differ from genome)Protein (651 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -961.003600-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023321 - PINIT
IPR003034 - SAP_DNA-bd
IPR004181 - Znf_MIZ

Pfam Domains:
PF02891 - MIZ/SP-RING zinc finger
PF14324 - PINIT domain

SCOP Domains:
68906 - SAP domain
57850 - RING/U-box
57903 - FYVE/PHD zinc finger

ModBase Predicted Comparative 3D Structure on Q2M4G9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsemblEnsemblWormBase 
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0061665 SUMO ligase activity

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0008542 visual learning
GO:0016925 protein sumoylation
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033235 positive regulation of protein sumoylation
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045444 fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0065004 protein-DNA complex assembly

Cellular Component:
GO:0005634 nucleus
GO:0016605 PML body


-  Descriptions from all associated GenBank mRNAs
  AK075708 - Mus musculus adult male lung cDNA, RIKEN full-length enriched library, clone:1200014K14 product:protein inhibitor of activated STAT 1, full insert sequence.
BC051417 - Mus musculus protein inhibitor of activated STAT 1, mRNA (cDNA clone MGC:58893 IMAGE:6515027), complete cds.
AK013753 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900068C24 product:PROTEIN INHIBITOR OF ACTIVATED STAT1 PROTEIN PIAS1 (DEAD/H BOX BINDING PROTEIN 1) homolog [Mus musculus], full insert sequence.
AF077950 - Mus musculus protein inhibitor of activated STAT protein PIAS1 mRNA, complete cds.
AK153871 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430001M22 product:protein inhibitor of activated STAT 1, full insert sequence.
AK142088 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230030N19 product:protein inhibitor of activated STAT 1, full insert sequence.
AK162584 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630037I10 product:protein inhibitor of activated STAT 1, full insert sequence.
AK136188 - Mus musculus in vitro fertilized eggs cDNA, RIKEN full-length enriched library, clone:7420472N23 product:protein inhibitor of activated STAT 1, full insert sequence.
AK028413 - Mus musculus 15 days embryo head cDNA, RIKEN full-length enriched library, clone:4022401D02 product:unclassifiable, full insert sequence.
AK034970 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430068K15 product:inferred: DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1, full insert sequence.
AK187989 - Mus musculus cDNA, clone:Y0G0143L10, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000034976, based on BLAT search.
AK035682 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530086I04 product:protein inhibitor of activated STAT 1, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04120 - Ubiquitin mediated proteolysis
mmu04630 - Jak-STAT signaling pathway
mmu05160 - Hepatitis C
mmu05200 - Pathways in cancer
mmu05222 - Small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
m_ranbp2Pathway - Sumoylation by RanBP2 Regulates Transcriptional Repression

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_9281, NM_019663, Q2M4G9, Q2M4G9_MOUSE, uc009qas.1, uc009qas.2
UCSC ID: uc009qas.2
RefSeq Accession: NM_019663
Protein: Q2M4G9 CCDS: CCDS40665.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.