Mouse Gene Anxa2 (ENSMUST00000034756.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus annexin A2 (Anxa2), mRNA. (from RefSeq NM_007585)
Gencode Transcript: ENSMUST00000034756.14
Gencode Gene: ENSMUSG00000032231.14
Transcript (Including UTRs)
   Position: mm10 chr9:69,453,620-69,491,795 Size: 38,176 Total Exon Count: 13 Strand: +
Coding Region
   Position: mm10 chr9:69,464,477-69,491,505 Size: 27,029 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:69,453,620-69,491,795)mRNA (may differ from genome)Protein (339 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q542G9_MOUSE
DESCRIPTION: RecName: Full=Annexin;
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity).
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.20137-0.498 Picture PostScript Text
3' UTR -82.90290-0.286 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR002389 - AnnexinII

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

ModBase Predicted Comparative 3D Structure on Q542G9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0008092 cytoskeletal protein binding
GO:0017137 Rab GTPase binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0042802 identical protein binding
GO:0044548 S100 protein binding
GO:0044730 bone sialoprotein binding
GO:0048306 calcium-dependent protein binding
GO:0098772 molecular function regulator

Biological Process:
GO:0001525 angiogenesis
GO:0001765 membrane raft assembly
GO:0001921 positive regulation of receptor recycling
GO:0001934 positive regulation of protein phosphorylation
GO:0006900 membrane budding
GO:0007589 body fluid secretion
GO:0030199 collagen fibril organization
GO:0031340 positive regulation of vesicle fusion
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0036035 osteoclast development
GO:0042730 fibrinolysis
GO:0043086 negative regulation of catalytic activity
GO:0044090 positive regulation of vacuole organization
GO:0044147 negative regulation of development of symbiont involved in interaction with host
GO:0048146 positive regulation of fibroblast proliferation
GO:0051099 positive regulation of binding
GO:0051290 protein heterotetramerization
GO:0052362 catabolism by host of symbiont protein
GO:0052405 negative regulation by host of symbiont molecular function
GO:0072659 protein localization to plasma membrane
GO:0097066 response to thyroid hormone
GO:1905581 positive regulation of low-density lipoprotein particle clearance
GO:1905597 positive regulation of low-density lipoprotein particle receptor binding
GO:1905599 positive regulation of low-density lipoprotein receptor activity
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport

Cellular Component:
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0030496 midbody
GO:0031902 late endosome membrane
GO:0031982 vesicle
GO:0032991 macromolecular complex
GO:0035749 myelin sheath adaxonal region
GO:0042383 sarcolemma
GO:0043220 Schmidt-Lanterman incisure
GO:0044354 macropinosome
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:1990667 PCSK9-AnxA2 complex


-  Descriptions from all associated GenBank mRNAs
  LF204657 - JP 2014500723-A/12160: Polycomb-Associated Non-Coding RNAs.
AK012563 - Mus musculus 11 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2700084K13 product:annexin A2, full insert sequence.
BC003327 - Mus musculus annexin A2, mRNA (cDNA clone MGC:7058 IMAGE:3156634), complete cds.
AK164507 - Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330016G14 product:annexin A2, full insert sequence.
AK168083 - Mus musculus TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730056L12 product:annexin A2, full insert sequence.
AK088645 - Mus musculus 2 days neonate thymus thymic cells cDNA, RIKEN full-length enriched library, clone:E430022F21 product:annexin A2, full insert sequence.
AK146096 - Mus musculus 12 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530029J12 product:annexin A2, full insert sequence.
AK152561 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830079G22 product:annexin A2, full insert sequence.
AK165888 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730014B17 product:annexin A2, full insert sequence.
AK150586 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830012H01 product:annexin A2, full insert sequence.
AK160746 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110004L04 product:annexin A2, full insert sequence.
AK167894 - Mus musculus CRL-1722 L5178Y-R cDNA, RIKEN full-length enriched library, clone:I730035J24 product:annexin A2, full insert sequence.
BC005763 - Mus musculus annexin A2, mRNA (cDNA clone MGC:6547 IMAGE:2655513), complete cds.
D10024 - Mus musculus mRNA for protein-tyrosine kinase substrate p36 (calpactin I heavy chain), complete cds.
M14044 - Mouse calpactin I heavy chain (p36) mRNA, complete cds.
MA440234 - JP 2018138019-A/12160: Polycomb-Associated Non-Coding RNAs.
AK087259 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030040G24 product:hypothetical protein, full insert sequence.
AK219954 - Mus musculus cDNA, clone:Y2G0150E04, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000034756, based on BLAT search.
BC004659 - Mus musculus annexin A2, mRNA (cDNA clone MGC:7718 IMAGE:3497991), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: CT009708.1-001, mCG_5731, NM_007585, Q542G9, Q542G9_MOUSE, uc009qng.1, uc009qng.2
UCSC ID: uc009qng.2
RefSeq Accession: NM_007585
Protein: Q542G9 CCDS: CCDS23316.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.