ID:NMNA3_MOUSE DESCRIPTION: RecName: Full=Nicotinamide mononucleotide adenylyltransferase 3; Short=NMN adenylyltransferase 3; EC=2.7.7.1; AltName: Full=Nicotinate-nucleotide adenylyltransferase 1; Short=NaMN adenylyltransferase 1; EC=2.7.7.18; FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury. CATALYTIC ACTIVITY: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). CATALYTIC ACTIVITY: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+). COFACTOR: Divalent metal cations. Magnesium confers the highest activity (By similarity). ENZYME REGULATION: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')- tetraphosphate (Nap4AD) (By similarity). PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Mitochondrion. DEVELOPMENTAL STAGE: Expressed throughout development and in adulthood. SIMILARITY: Belongs to the eukaryotic NMN adenylyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99JR6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0009058 biosynthetic process GO:0009435 NAD biosynthetic process GO:0009611 response to wounding GO:0019363 pyridine nucleotide biosynthetic process GO:0034628 'de novo' NAD biosynthetic process from aspartate
AK016744 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4933408N02 product:unclassifiable, full insert sequence. BC005737 - Mus musculus nicotinamide nucleotide adenylyltransferase 3, mRNA (cDNA clone MGC:11917 IMAGE:3599134), complete cds. AK040783 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530024M19 product:unclassifiable, full insert sequence. AK041526 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630019F12 product:similar to FKSG76 [Homo sapiens], full insert sequence. AK041897 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630045I16 product:similar to FKSG76 [Homo sapiens], full insert sequence. BC092086 - Mus musculus nicotinamide nucleotide adenylyltransferase 3, mRNA (cDNA clone MGC:102340 IMAGE:5040019), complete cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00760 - Nicotinate and nicotinamide metabolism mmu01100 - Metabolic pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99JR6 (Reactome details) participates in the following event(s):
R-MMU-200474 NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD R-MMU-196807 Nicotinate metabolism R-MMU-196849 Metabolism of water-soluble vitamins and cofactors R-MMU-196854 Metabolism of vitamins and cofactors R-MMU-1430728 Metabolism
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