Mouse Gene Mobp (ENSMUST00000093773.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus myelin-associated oligodendrocytic basic protein (Mobp), transcript variant 1, mRNA. (from RefSeq NM_008614)
Gencode Transcript: ENSMUST00000093773.7
Gencode Gene: ENSMUSG00000032517.16
Transcript (Including UTRs)
   Position: mm10 chr9:120,149,742-120,176,091 Size: 26,350 Total Exon Count: 4 Strand: +
Coding Region
   Position: mm10 chr9:120,167,805-120,173,190 Size: 5,386 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:120,149,742-120,176,091)mRNA (may differ from genome)Protein (81 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: MOBP_MOUSE
DESCRIPTION: RecName: Full=Myelin-associated oligodendrocyte basic protein;
FUNCTION: May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Note=Present in the major dense line of CNS myelin (By similarity).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.20139-0.203 Picture PostScript Text
3' UTR -1011.902901-0.349 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026666 - Mobp

Pfam Domains:
PF02318 - FYVE-type zinc finger

SCOP Domains:
57924 - Inhibitor of apoptosis (IAP) repeat

ModBase Predicted Comparative 3D Structure on Q9D2P8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0017022 myosin binding
GO:0017137 Rab GTPase binding
GO:0019911 structural constituent of myelin sheath

Biological Process:
GO:0030050 vesicle transport along actin filament

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0030864 cortical actin cytoskeleton
GO:0043209 myelin sheath
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF197868 - JP 2014500723-A/5371: Polycomb-Associated Non-Coding RNAs.
MA433445 - JP 2018138019-A/5371: Polycomb-Associated Non-Coding RNAs.
AK019323 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900029K09 product:myelin-associated oligodendrocytic basic protein, full insert sequence.
BC048492 - Mus musculus myelin-associated oligodendrocytic basic protein, mRNA (cDNA clone MGC:58309 IMAGE:6593408), complete cds.
AK140055 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230113L23 product:myelin-associated oligodendrocytic basic protein, full insert sequence.
AK028057 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500035N02 product:myelin-associated oligodendrocytic basic protein, full insert sequence.
AK013799 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:2900076O11 product:myelin-associated oligodendrocytic basic protein, full insert sequence.
AK083103 - Mus musculus adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630014L05 product:myelin-associated oligodendrocytic basic protein, full insert sequence.
U81317 - Mus musculus myelin-associated/oligodendrocyte basic protein (Mobp) mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: MOBP_MOUSE, NM_008614, O35713, Q792D7, Q792D8, Q9D2P8, Q9JLY4, Q9JLY5, Q9JLY6, uc009sck.1
UCSC ID: uc009sck.1
RefSeq Accession: NM_008614
Protein: Q9D2P8 (aka MOBP_MOUSE)
CCDS: CCDS40808.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.