Mouse Gene Ackr2 (ENSMUST00000050327.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus atypical chemokine receptor 2 (Ackr2), transcript variant 2, mRNA. (from RefSeq NM_021609)
Gencode Transcript: ENSMUST00000050327.4
Gencode Gene: ENSMUSG00000044534.8
Transcript (Including UTRs)
   Position: mm10 chr9:121,898,395-121,911,064 Size: 12,670 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm10 chr9:121,908,561-121,909,697 Size: 1,137 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:121,898,395-121,911,064)mRNA (may differ from genome)Protein (378 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: CCBP2_MOUSE
DESCRIPTION: RecName: Full=Chemokine-binding protein 2; AltName: Full=C-C chemokine receptor D6; AltName: Full=Chemokine-binding protein D6;
FUNCTION: Receptor for C-C type chemokines including SCY3/MIP1- alpha and SCYA4/MIP-1-beta.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.80349-0.329 Picture PostScript Text
3' UTR -419.401367-0.307 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001277 - Chemokine_CXCR4
IPR000355 - Chemokine_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on O08707
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004950 chemokine receptor activity
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0019957 C-C chemokine binding

Biological Process:
GO:0006898 receptor-mediated endocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway

Cellular Component:
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055037 recycling endosome


-  Descriptions from all associated GenBank mRNAs
  AK157140 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830204C03 product:chemokine binding protein 2, full insert sequence.
AK147166 - Mus musculus 17 days pregnant adult female amnion cDNA, RIKEN full-length enriched library, clone:I920193A19 product:chemokine binding protein 2, full insert sequence.
AK028281 - Mus musculus 14, 17 days embryo head cDNA, RIKEN full-length enriched library, clone:3222402L07 product:D6 beta-chemokine receptor, full insert sequence.
AK145960 - Mus musculus 12 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530018A07 product:chemokine binding protein 2, full insert sequence.
Y12879 - M.musculus mRNA for beta-chemokine receptor D6.
BC113146 - Mus musculus chemokine binding protein 2, mRNA (cDNA clone MGC:130576 IMAGE:40055448), complete cds.
DQ288244 - Mus musculus chemokine-binding protein 2 (Ccbp2) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: Ccbp2, CCBP2_MOUSE, D6, NM_021609, O08707, Q8CEG1, uc009sed.1, uc009sed.2, uc009sed.3
UCSC ID: uc009sed.3
RefSeq Accession: NM_021609
Protein: O08707 (aka CCBP2_MOUSE or CKD6_MOUSE)
CCDS: CCDS23640.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.