Mouse Gene Pim2 (ENSMUST00000033495.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt F6WGR1)
Gencode Transcript: ENSMUST00000033495.14
Gencode Gene: ENSMUSG00000031155.16
Transcript (Including UTRs)
   Position: mm10 chrX:7,878,302-7,883,432 Size: 5,131 Total Exon Count: 6 Strand: +
Coding Region
   Position: mm10 chrX:7,878,302-7,882,517 Size: 4,216 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:7,878,302-7,883,432)mRNA (may differ from genome)Protein (374 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F6WGR1_MOUSE
DESCRIPTION: SubName: Full=Serine/threonine-protein kinase pim-2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -303.10915-0.331 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF06293 - Lipopolysaccharide kinase (Kdo/WaaP) family
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on F6WGR1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0043066 negative regulation of apoptotic process


-  Descriptions from all associated GenBank mRNAs
  AK043570 - Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830008N09 product:proviral integration site 2, full insert sequence.
L41495 - Mus musculus protein-serine/threonine kinase (pim-2) mRNA, complete cds.
BC027376 - Mus musculus proviral integration site 2, mRNA (cDNA clone MGC:37188 IMAGE:4954711), complete cds.
BC022727 - Mus musculus proviral integration site 2, mRNA (cDNA clone IMAGE:4504592), partial cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu05221 - Acute myeloid leukemia

-  Other Names for This Gene
  Alternate Gene Symbols: F6WGR1, F6WGR1_MOUSE, L41495, uc009smz.1, uc009smz.2, uc009smz.3
UCSC ID: uc009smz.3
RefSeq Accession: NM_138606
Protein: F6WGR1 CCDS: CCDS29976.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.