Mouse Gene Ndufb11 (ENSMUST00000116621.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus NADH:ubiquinone oxidoreductase subunit B11 (Ndufb11), transcript variant 1, mRNA. (from RefSeq NM_019435)
Gencode Transcript: ENSMUST00000116621.1
Gencode Gene: ENSMUSG00000031059.9
Transcript (Including UTRs)
   Position: mm10 chrX:20,615,326-20,617,619 Size: 2,294 Total Exon Count: 3 Strand: -
Coding Region
   Position: mm10 chrX:20,615,419-20,617,260 Size: 1,842 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:20,615,326-20,617,619)mRNA (may differ from genome)Protein (151 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NDUBB_MOUSE
DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; AltName: Full=Complex I-ESSS; Short=CI-ESSS; AltName: Full=NADH-ubiquinone oxidoreductase ESSS subunit; AltName: Full=Neuronal protein 15.6; Short=Np15.6; Short=p15.6; Flags: Precursor;
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
SUBUNIT: Complex I is composed of 45 different subunits (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the complex I NDUFB11 subunit family.
SEQUENCE CAUTION: Sequence=AAH27265.1; Type=Erroneous initiation; Sequence=BAC25760.1; Type=Erroneous initiation; Sequence=CAA69961.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -92.50359-0.258 Picture PostScript Text
3' UTR -17.0093-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019329 - NADH_UbQ_OxRdtase_ESSS_su

Pfam Domains:
PF10183 - ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

ModBase Predicted Comparative 3D Structure on O09111
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsemblEnsembl  
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  LF201915 - JP 2014500723-A/9418: Polycomb-Associated Non-Coding RNAs.
BC096047 - Mus musculus NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, mRNA (cDNA clone IMAGE:1515391), partial cds.
Y08702 - M.musculus mRNA for neuronal protein 15.6.
BC027265 - Mus musculus NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, mRNA (cDNA clone MGC:27951 IMAGE:3589704), complete cds.
AK028121 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010317F12 product:neuronal protein 15.6, full insert sequence.
LF310983 - JP 2014500723-A/118486: Polycomb-Associated Non-Coding RNAs.
LF310984 - JP 2014500723-A/118487: Polycomb-Associated Non-Coding RNAs.
LF310985 - JP 2014500723-A/118488: Polycomb-Associated Non-Coding RNAs.
MA437492 - JP 2018138019-A/9418: Polycomb-Associated Non-Coding RNAs.
MA546560 - JP 2018138019-A/118486: Polycomb-Associated Non-Coding RNAs.
MA546561 - JP 2018138019-A/118487: Polycomb-Associated Non-Coding RNAs.
MA546562 - JP 2018138019-A/118488: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00190 - Oxidative phosphorylation
mmu05010 - Alzheimer's disease
mmu05012 - Parkinson's disease
mmu05016 - Huntington's disease

BioCyc Knowledge Library
PWY-3781 - aerobic respiration -- electron donor II
PWY0-1334 - NADH to cytochrome bd oxidase electron transfer
PWY0-1335 - NADH to cytochrome bo oxidase electron transfer

Reactome (by CSHL, EBI, and GO)

Protein O09111 (Reactome details) participates in the following event(s):

R-MMU-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2
R-MMU-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex
R-MMU-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
R-MMU-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex
R-MMU-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex
R-MMU-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
R-MMU-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2
R-MMU-6799198 Complex I biogenesis
R-MMU-611105 Respiratory electron transport
R-MMU-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-MMU-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: NDUBB_MOUSE, NM_019435, Np15, O09111, uc009ste.1, uc009ste.2, uc009ste.3
UCSC ID: uc009ste.3
RefSeq Accession: NM_019435
Protein: O09111 (aka NDUBB_MOUSE)
CCDS: CCDS53012.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.