Mouse Gene Apln (ENSMUST00000039026.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus apelin (Apln), mRNA. (from RefSeq NM_013912) RefSeq Summary (NM_013912): This gene encodes the neuropeptide Apelin, an endogenous ligand of the G protein-coupled receptor APJ. This gene is highly expressed in the central nervous system and peripheral tissues and the encoded preproprotein undergoes proteolytic processing to generate mature peptides of different sizes that are secreted into the plasma. These peptides play important roles in a broad range of physiological processes such as cardiac contractility, blood pressure, blood vessel growth, appetite and drink behavior, and pituitary hormone secretion. Mice lacking the encoded protein develop progressive heart failure and exhibit a shorter bleeding time, prothrombotic profile and increased bone mass. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENSMUST00000039026.7 Gencode Gene: ENSMUSG00000037010.7 Transcript (Including UTRs) Position: mm10 chrX:48,025,146-48,034,853 Size: 9,708 Total Exon Count: 3 Strand: - Coding Region Position: mm10 chrX:48,028,299-48,034,505 Size: 6,207 Coding Exon Count: 2
ID:APEL_MOUSE DESCRIPTION: RecName: Full=Apelin; AltName: Full=APJ endogenous ligand; Contains: RecName: Full=Apelin-36; Contains: RecName: Full=Apelin-31; Contains: RecName: Full=Apelin-28; Contains: RecName: Full=Apelin-13; Flags: Precursor; FUNCTION: Endogenous ligand for APJ. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross- linking. The oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. PTM: Several active peptides may be produced by proteolytic processing of the peptide precursor. SIMILARITY: Belongs to the apelin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9R0R4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
