Human Gene RCAN3 (ENST00000436717.6) from GENCODE V44
  Description: Homo sapiens RCAN family member 3 (RCAN3), transcript variant 6, mRNA. (from RefSeq NM_001251981)
Gencode Transcript: ENST00000436717.6
Gencode Gene: ENSG00000117602.13
Transcript (Including UTRs)
   Position: hg38 chr1:24,502,897-24,537,019 Size: 34,123 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr1:24,514,373-24,535,277 Size: 20,905 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:24,502,897-24,537,019)mRNA (may differ from genome)Protein (183 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RCAN3_HUMAN
DESCRIPTION: RecName: Full=Calcipressin-3; AltName: Full=Down syndrome candidate region 1-like protein 2; AltName: Full=Myocyte-enriched calcineurin-interacting protein 3; Short=MCIP3; AltName: Full=Regulator of calcineurin 3;
FUNCTION: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity).
TISSUE SPECIFICITY: Highest expression in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Lower expression in all other tissues.
SIMILARITY: Belongs to the RCAN family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RCAN3
Diseases sorted by gene-association score: down syndrome (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.01 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 57.82 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -137.20280-0.490 Picture PostScript Text
3' UTR -466.801742-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006931 - Calcipressin
IPR012677 - Nucleotide-bd_a/b_plait

Pfam Domains:
PF04847 - Calcipressin

ModBase Predicted Comparative 3D Structure on Q9UKA8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity
GO:0019902 phosphatase binding
GO:0031013 troponin I binding

Biological Process:
GO:0009653 anatomical structure morphogenesis
GO:0019722 calcium-mediated signaling
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0070884 regulation of calcineurin-NFAT signaling cascade

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  JN228252 - Homo sapiens regulator of calcineurin 3 isoform 1a,2,3,4,5 (RCAN3) mRNA, partial cds, alternatively spliced.
GQ411200 - Homo sapiens regulator of calcineurin 3 isoform 1a,2,3,4 (RCAN3) mRNA, partial cds, alternatively spliced.
HQ317421 - Homo sapiens regulator of calcineurin 3 isoform 1a,2,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
HQ317422 - Homo sapiens regulator of calcineurin 3 isoform 1a,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
LF383920 - JP 2014500723-A/191423: Polycomb-Associated Non-Coding RNAs.
MA619497 - JP 2018138019-A/191423: Polycomb-Associated Non-Coding RNAs.
BC035854 - Homo sapiens RCAN family member 3, mRNA (cDNA clone MGC:46109 IMAGE:5770066), complete cds.
HQ287726 - Homo sapiens regulator of calcineurin 3 isoform 1,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
HQ317445 - Homo sapiens regulator of calcineurin 3 isoform 1b,2 (RCAN3) mRNA, partial cds, alternatively spliced.
HQ317446 - Homo sapiens regulator of calcineurin 3 isoform 1b,2 (RCAN3) mRNA, partial cds, alternatively spliced.
HQ317423 - Homo sapiens regulator of calcineurin 3 isoform 1b,2,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
HQ317426 - Homo sapiens regulator of calcineurin 3 isoform 1c,2,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
JN203053 - Homo sapiens regulator of calcineurin 3 isoform 1c,2,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
EF467309 - Homo sapiens regulator of calcineurin 3 isoform 2,3,5 (DSCR1L2) mRNA, complete cds, alternatively spliced.
EF431960 - Homo sapiens regulator of calcineurin 3 isoform 2,4,5 (DSCR1L2) mRNA, complete cds, alternatively spliced.
EF529733 - Homo sapiens regulator of calcineurin 3 isoform 2,4,5 (DSCR1L2) mRNA, complete cds, alternatively spliced.
AF176116 - Homo sapiens regulator of calcineurin 3 (DSCR1L2) mRNA, complete cds.
DQ892434 - Synthetic construct clone IMAGE:100005064; FLH186294.01X; RZPDo839C1271D Down syndrome critical region gene 1-like 2 (DSCR1L2) gene, encodes complete protein.
DQ895645 - Synthetic construct Homo sapiens clone IMAGE:100010105; FLH186290.01L; RZPDo839C1261D Down syndrome critical region gene 1-like 2 (DSCR1L2) gene, encodes complete protein.
KJ898362 - Synthetic construct Homo sapiens clone ccsbBroadEn_07756 RCAN3 gene, encodes complete protein.
AY906854 - Homo sapiens regulator of calcineurin 3 isoform 2,5 (DSCR1L2) mRNA, complete cds, alternatively spliced.
AF176117 - Homo sapiens regulator of calcineurin 3 isoform 2,3,4b,5 (DSCR1L2) mRNA, partial cds, alternatively spliced.
HQ317427 - Homo sapiens regulator of calcineurin 3 isoform 1c,3,4,5 (RCAN3) mRNA, complete cds, alternatively spliced.
LF357003 - JP 2014500723-A/164506: Polycomb-Associated Non-Coding RNAs.
MA592580 - JP 2018138019-A/164506: Polycomb-Associated Non-Coding RNAs.
JD216795 - Sequence 197819 from Patent EP1572962.
LF357002 - JP 2014500723-A/164505: Polycomb-Associated Non-Coding RNAs.
MA592579 - JP 2018138019-A/164505: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: DSCR1L2, ENST00000436717.1, ENST00000436717.2, ENST00000436717.3, ENST00000436717.4, ENST00000436717.5, NM_001251981, Q5TGC6, Q9NUC8, Q9UKA7, Q9UKA8, RCAN3_HUMAN, uc009vre.1, uc009vre.2, uc009vre.3, uc009vre.4
UCSC ID: ENST00000436717.6
RefSeq Accession: NM_001251981
Protein: Q9UKA8 (aka RCAN3_HUMAN)
CCDS: CCDS57981.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.