ID:RPRD2_HUMAN DESCRIPTION: RecName: Full=Regulation of nuclear pre-mRNA domain-containing protein 2; SUBUNIT: Associates with the RNA polymerase II complex. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 CID domain. SEQUENCE CAUTION: Sequence=AAF28922.1; Type=Erroneous initiation; Sequence=AAH45623.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5VT52
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0042795 snRNA transcription from RNA polymerase II promoter
Cellular Component: GO:0005654 nucleoplasm GO:0016591 DNA-directed RNA polymerase II, holoenzyme
Descriptions from all associated GenBank mRNAs
AK125864 - Homo sapiens cDNA FLJ43876 fis, clone TESTI4008816. BX641025 - Homo sapiens mRNA; cDNA DKFZp686H22247 (from clone DKFZp686H22247). AK304380 - Homo sapiens cDNA FLJ54323 complete cds. AK291703 - Homo sapiens cDNA FLJ78236 complete cds. AK308148 - Homo sapiens cDNA, FLJ98096. AK056707 - Homo sapiens cDNA FLJ32145 fis, clone PLACE5000113, weakly similar to GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3). BC045623 - Homo sapiens regulation of nuclear pre-mRNA domain containing 2, mRNA (cDNA clone MGC:39541 IMAGE:5269891), complete cds. AB007929 - Homo sapiens mRNA for KIAA0460 protein, partial cds. EU832542 - Synthetic construct Homo sapiens clone HAIB:100067571; DKFZo004B0830 KIAA0460 protein (KIAA0460) gene, encodes complete protein. EU832573 - Synthetic construct Homo sapiens clone HAIB:100067602; DKFZo004E1130 KIAA0460 protein (KIAA0460) gene, encodes complete protein. EU832460 - Synthetic construct Homo sapiens clone HAIB:100067489; DKFZo008B0829 KIAA0460 protein (KIAA0460) gene, encodes complete protein. EU832492 - Synthetic construct Homo sapiens clone HAIB:100067521; DKFZo008E1129 KIAA0460 protein (KIAA0460) gene, encodes complete protein. AB527168 - Synthetic construct DNA, clone: pF1KA0460, Homo sapiens KIAA0460 gene for regulation of nuclear pre-mRNA domain containing 2, without stop codon, in Flexi system. JD416360 - Sequence 397384 from Patent EP1572962. AF161362 - Homo sapiens HSPC099 mRNA, partial cds. AK022984 - Homo sapiens cDNA FLJ12922 fis, clone NT2RP2004664, highly similar to Homo sapiens mRNA for KIAA0460 protein. AK026120 - Homo sapiens cDNA: FLJ22467 fis, clone HRC10345.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q5VT52 (Reactome details) participates in the following event(s):
R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
