Human Gene KCNC1 (ENST00000265969.8) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel subfamily C member 1 (KCNC1), transcript variant 1, mRNA. (from RefSeq NM_001112741) RefSeq Summary (NM_001112741): This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]. Gencode Transcript: ENST00000265969.8 Gencode Gene: ENSG00000129159.9 Transcript (Including UTRs) Position: hg38 chr11:17,734,781-17,783,057 Size: 48,277 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr11:17,736,003-17,781,734 Size: 45,732 Coding Exon Count: 4
ID:KCNC1_HUMAN DESCRIPTION: RecName: Full=Potassium voltage-gated channel subfamily C member 1; AltName: Full=NGK2; AltName: Full=Voltage-gated potassium channel subunit Kv3.1; AltName: Full=Voltage-gated potassium channel subunit Kv4; FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. SUBUNIT: Heteromultimer with KCNG3, KCNG4 and KCNV2. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. DOMAIN: The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. SIMILARITY: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00520 - Ion transport protein PF02214 - BTB/POZ domain
ModBase Predicted Comparative 3D Structure on P48547
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0007420 brain development GO:0009636 response to toxic substance GO:0009642 response to light intensity GO:0010996 response to auditory stimulus GO:0014075 response to amine GO:0021549 cerebellum development GO:0021759 globus pallidus development GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035690 cellular response to drug GO:0035864 response to potassium ion GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0055085 transmembrane transport GO:0071774 response to fibroblast growth factor GO:0071805 potassium ion transmembrane transport GO:1901379 regulation of potassium ion transmembrane transport GO:1901381 positive regulation of potassium ion transmembrane transport GO:1903818 positive regulation of voltage-gated potassium channel activity GO:1990089 response to nerve growth factor
US Server
